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Poster display - Cocktail

996 - The impact of continuing ALK inhibitors beyond initial disease progression on clinical outcome in patients with advanced ALK-positive non-small cell lung cancer: Results of a multicenter retrospective analysis


24 Nov 2018


Poster display - Cocktail


Shinya Sakata


Annals of Oncology (2018) 29 (suppl_9): ix150-ix169. 10.1093/annonc/mdy425


S. Sakata1, S. Saeki1, Y. Sakata2, K. Kawamura2, K. Ichikado2, M. Inaba3, S. Ushijima3, K. Imamura4, K. Iyonaga4, T. Kumabe5, R. Fujita5, K. Kashiwabara6, S. Fujii6, T. Komatsu7, O. Sakamoto7, H. Okabayashi8, K. Saruwatari1, Y. Tomita1, T. Sakagami1

Author affiliations

  • 1 Respiratory Medicine, Kumamoto University Hospital, 860-8556 - Kumamoto city/JP
  • 2 Respiratory Medicine, Saiseikai Kumamoto Hospital, Kumamoto city/JP
  • 3 Respiratory Medicine, Kumamoto Chuo Hospital, Kumamoto city/JP
  • 4 Respiratory Medicine, Japanese Red Cross Kumamoto Hospital, Kumamoto city/JP
  • 5 Internal Medicine, Miyazaki prefectural Nobeoka Hospital, Nobeoka/JP
  • 6 Respiratory Medicine, Kumamoto Regional Medical Center, Kumamoto city/JP
  • 7 Respiratory Medicine, Kumamoto Saishunso Hospital, Kumamoto city/JP
  • 8 Respiratory Medicine, Omuta Tenryo Hospital, Omuta/JP


Abstract 996


The efficacy of continuing anaplastic lymphoma kinase (ALK) tyrosine kinase inhibitors (TKIs) beyond initial disease progression for ALK-positive patients with advanced non-small cell lung cancer (NSCLC) has not been fully understood.


We retrospectively analyzed 74 ALK-positive advanced NSCLC patients who received ALK-TKIs between August 2011 and July 2017 in Kumamoto university hospital and community hospitals in Japan. Continuation of ALK-TKIs beyond progressive disease (PD) was defined as > 3 weeks of ALK-TKIs treatment after PD confirmation.


Among 74 patients, 32 received alectinib treatment and 42 received crizotinib as first ALK-TKI treatments. Progression free survival of patients with alectinib was significantly longer than that of crizotinib in the ALK inhibitor-naïve population (32.8 months versus 13.3 months, P = 0.005). Forty-one patients among the 74 patients treated with ALK-TKIs had RECIST-defined PD. Eleven of 41 RECIST-defined PD patients continued ALK-TKI therapy. The median time to tumor progression of these 11 patients was 11.7 months. The median overall survival of patients with or without continuation of ALK-TKIs beyond initial PD was 59.7 months versus 51.2 months, respectively (P = 0.35).


Continuing ALK inhibition with crizotinib or alectinib after initial PD may provide survival benefit to patients with advanced ALK-positive NSCLC.

Editorial acknowledgement

Clinical trial identification

Legal entity responsible for the study

Shinya Sakata.


Has not received any funding.


All authors have declared no conflicts of interest.

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