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Poster display - Cocktail

737 - Survival patterns of pediatric neuroblastoma at different primary sites

Date

24 Nov 2018

Session

Poster display - Cocktail

Presenters

Amira Diab

Citation

Annals of Oncology (2018) 29 (suppl_9): ix170-ix172. 10.1093/annonc/mdy433

Authors

A.H. Diab1, I.O. Uthman2

Author affiliations

  • 1 Under Graduate, Faculty of Medicine, Suez Canal University, 41111 - Ismailia/EG
  • 2 Under Graduate, Faculty of Medicine, Suez Canal University, 41511 - Ismailia/EG
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Resources

Abstract 737

Background

Neuroblastoma represents 7.8% of all cancers in children in the United States, with more than 600 new cases are diagnosed annually. The incidence of the disease differs according to age, race and primary site. We conducted this study to identify the survival pattern of neuroblastoma arising from different primary sites.

Methods

Using the SEER database, we extracted the data of 1336 patients with neuroblastoma from 2000 to 2010, age less or equal to 10 years old. We selected neuroblastoma arising from the adrenal gland, peripheral nerves&autonomic nervous system, mediastinum, and peritoneum.

Results

Adrenal gland was the most frequent primary site for neuroblastoma to occur, with 819(61.3%) documented cases. Better outcomes were observed in children younger than 1 year of age (91.4%), those of a white race (74.6%), and those with tumors arising from the mediastinum (87.7%). However, we found no significant difference in overall survival between males and females.

Table: 552P

VariablesOverall survivalP-value
Age 00 1-2 3-1091.4% 68.7% 53.2%0.000**
sex Male female72.6% 72.8%0.607
race White black Others74.6% 66.3% 63.5%0.007*
primary site adrenal gland retro-peritoneum mediastinum peripheral nerves/ANS67.9% 72.3% 87.7% 82.2%0.000**
*

Significant p-value at ≤ 0.001

**

Highly significant p-value at ≤ 0.001 ANS: autonomic nervous system

Conclusions

Children younger than 1year, of a white race, and/or with tumor arising at the mediastinum had better 5-year overall survival.

Editorial acknowledgement

Inas Uthman.

Clinical trial identification

Legal entity responsible for the study

Amira Diab.

Funding

Has not received any funding.

Disclosure

All other authors have declared no conflicts of interest.

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