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Poster display - Cocktail

1309 - Superior antitumor efficacy of interferon incorporated hydrogels combined with CIK and radiation against gastric cancer

Date

24 Nov 2018

Session

Poster display - Cocktail

Presenters

Qin Liu

Citation

Annals of Oncology (2018) 29 (suppl_9): ix46-ix66. 10.1093/annonc/mdy432

Authors

Q. Liu, D. Zhang, H. Qian, B. Liu

Author affiliations

  • Clinical Cancer Institute Of Nanjing University, The Comprehensive Cancer Center, Affiliated Drum Tower Hospital,Medical School of Nanjing University, 210008 - Nanjing/CN
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Resources

Abstract 1309

Background

Cytokine-induced killer (CIK) cells are often compromised by their lack of tumor targeting and long-term activity against solid tumors. Herein, we report an interferon-α (IFN-α) encapsulated hydrogel and low dose irradiation (LDI) as CIK sensitizers for gastric cancer therapy.

Methods

IFN-α2b was incorporated in an ultraviolet-reactive, rapidly cross-linkable hydroxypropyl cellulose (HPC) hydrogel. The physicochemical and drug release profiles were characterized. The CIK accumulation upon LDI at tumor site was invesigated. The antitumor efficacy of combining CIK cells, IFN-α2b loaded hydrogels and LDI was explored in a gastric cancer xenografted mouse model.

Results

The HPC hydrogels exhibited a porous structure, consisting of open pore channels and an interconnected framework. The bioactivity of IFN-α2b was well-maintained in the hydrogels with constant release profile. CIK cells accumulated into tumors irradiated by a 5 Gy dose, indicating local LDI provided the possibility of recruitment of immune cells to the tumor site. The tumor growth inhibition on gastric cancer bearing mice was 59% of Gel-IFN + CIK + LDI group, which was higher than the IFN-a2b alone (11.7%, P < 0.01) and IFN-a2b + CIK + LDI (43.3%, P < 0.01). The tumor weight inhibition was 52%, while they were 4.7% and 33.0% in IFN-a2b alone and IFN-a2b + CIK + LDI, respectively (P < 0.01).

Conclusions

This innovative combination of CIK cells, IFN-α2b loaded hydrogels with cancer radiation serve as a potent strategy for gastric cancer treatment.

Editorial acknowledgement

Clinical trial identification

Legal entity responsible for the study

Nanjing Drum Tower Hospital.

Funding

Has not received any funding.

Disclosure

All authors have declared no conflicts of interest.

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