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Role of Tie2, CD14, angiopoietin as angiogenetic markers in hepatocellular carcinoma complicating hepatitis C virus infection in Egyptian patients

Date

24 Nov 2018

Session

Poster display - Cocktail

Presenters

El-zahraa Meghezel

Citation

Annals of Oncology (2018) 29 (suppl_9): ix46-ix66. 10.1093/annonc/mdy432

Authors

E.M. Meghezel1, H. Abdelhfez Ahmed2, A.A. Askar3, E.E.N. Hassan4, A. Elyamany5

Author affiliations

  • 1 Tropical Medicine And Gastroenterology, Sohag University., 002 - sohag/EG
  • 2 Clinical Pathology, Sohag University., 002 - sohag/EG
  • 3 Internal Medicine, Sohag University., 002 - sohag/EG
  • 4 Emad Eldin Nabil Hassan, Sohag University., 002 - sohag/EG
  • 5 Medical Oncology, South Egypt Cancer Institute SECI Assiut University, 7151 - Assiut/EG
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Background

Hepatocellular carcinoma (HCC) is the second most common worldwide cancer, but biomarkers for early detection remain challengeable. TIE2-expressing monocyte (TEMs) cells display pro-tumoral activities. The aim of the study was to examine the expression of TEM which is defined as CD14+ TIE2+ and angiopoietin-2 in hepatocellular carcinoma and its potential use as a diagnostic tumor marker in HCC patients with HCV induced liver cirrhosis.

Methods

This study was conducted on 112 Patients admitted to our tropical medicine department and 38 controls divided into two groups: Group I comprised 78 patients with HCC; group II comprised 34 patients with cirrhosis. Both groups were compared with 38 (age and sex-matched) healthy persons as group III.

Results

level of TEMs & serum Ang-2 were significantly higher in HCC patients compared with liver cirrhotic patients and healthy controls. Sensitivity & specificity in diagnosis of HCC respectively were CD14 (89.7%, 83.3%), TIE 2 (76.9%, 83.3%). Ang-2 (76.9%, 66.7%).

Conclusions

These results suggest that TEMs & Ang-2 increase in patients with HCC supporting the idea that TEMs & Ang-2 can be used as a diagnostic marker for HCC, especially among the high-risk group of patients.

Editorial acknowledgement

Clinical trial identification

Legal entity responsible for the study

Sohag University Ethical Comittee.

Funding

Has not received any funding.

Disclosure

All authors have declared no conflicts of interest.

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