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Poster display - Cocktail

1337 - Painful scalp during chemotherapy induced hair loss is associated to permanent alopecia in breast cancer patients

Date

24 Nov 2018

Session

Poster display - Cocktail

Presenters

Nesrine Mejri

Citation

Annals of Oncology (2018) 29 (suppl_9): ix1-ix7. 10.1093/annonc/mdy426

Authors

N. Mejri1, M. Saadi2, F. Guermazi1, H. El Benna2, N. Daoud1, S. Labidi1, H. Boussen1

Author affiliations

  • 1 Medical Oncology, Hospital Abderrahmane Mami, 2080 - Tunis/TN
  • 2 Medical Oncology, Hospital Abderrahmane Mami, Tunis/TN
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Resources

Abstract 1337

Background

We aimed to study characteristics of chemotherapy-induced alopecia (CIA) and recovery during and after chemotherapy for early breast cancer and to evaluate factors associated to permanent alopecia.

Methods

Between February and April 2018, we conducted a telephone interview survey of 149 patients who had completed neo/adjuvant chemotherapy for breast cancer since at least 6 months. The questionnaire asked questions about characteristics of hair loss occurrence and regrowth. Clinical and therapeutic data were collected from patient’s records. Permanent alopecia was defined as the absence of complete or partial hair regrowth after 6 months of the end of chemotherapy. Ki2 Pearson test and odd ratio were used to evaluate risk factors.

Results

Median age was 48 years [30-73], 95% received sequential chemotherapy. CIA was seen in 98% of patients (Grade I in 16.1% and Grade II in 83.9%). Initial alopecia occurred during the first cycle in 29.7%, the second cycle in 45.9% and the third cycle in 24.4%. Hair loss was painful in 44.3%. Hair recovery started after a median of 3.15 months. Patients reported a change of hair colour into white in 16.8% and into a different color then before in 21.5%. A change of hair texture was seen in 51% of cases (35.6% softer, 15.4% less soft). Hair regrowth started the same way in all scalp in 77.9% and only one region then the others in 22.1%. Patients used medical/natural treatments in order to reduce hair loss in 24.8%. After a median time since the end of chemotherapy of 2.8 years, incidence of complete permanent alopecia was 1.7% and partial permanent alopecia was 22.1% (total 23.8%). Among all studied factors (Table), patients with permanent alopecia significantly experienced more pain during CIA (60% vs 39%, p = 0.03), with an odds ratio of 2.34.Table: 17P

Evaluation of permanent alopecia possible risk factors using Ki2 Pearson test

Permanent Alopecia (complete and partial) (23.8%)Non-permanent Alopecia (76.2%)p
Adjuvant endocrine therapy69%57%0.43
BMI>3049.1%33.3%0.1
More then 3 full pregnancies39%40%0.9
Breastfeeding>12 months21%19%0.7
Menopaused36%43%0.4
Age at diagnosis <4018%20%0.7
Age at diagnosis >656%6%0.8
Alopecia since the first cycle30%29%0.9
Pain during hair loss60%39%0.03
Start hair recovery >6 months of the end of chemotherapy18%10%0.2

Conclusions

Our study described several aspects of symptoms, chronology and topography of hair loss and regrowth after CT for early breast cancer. Pain during hair loss may reflect a severe stress in hair follicles which may be associated to subsequent hair regrowth issues.

Editorial acknowledgement

Clinical trial identification

Legal entity responsible for the study

Medical Oncology Department, Abderrahmen Mami Hospital.

Funding

Has not received any funding.

Disclosure

All authors have declared no conflicts of interest.

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