Systematic inflammation responses have been proved as the metastatic and proactivity tumor factors through apoptosis inhibition, angiogenesis promotion and DNA decays. Eosinophil lymphocyte ratio (ELR) is a factor used as indicators of inflammation. This study aimed to investigate the relationship between ELR and subtype of patients with breast cancer in Sanglah Hospital, Bali.
An analytical cross-sectional study was conducted using secondary data from medical records among 105 breast cancer patients during the 2013-2015 period. Consecutive sampling technique was used in this study by considering exclusion and inclusion criteria. A subtype of breast cancers was divided into luminal (A and B) and non-luminal (Her-2 and TNBC). Data were analyzed using SPSS ver. 16 in mean±SD, percentage, and odds ratio (OR).
The average age of subjects was 50.44±1.06 years-old and about 34.3% were stage IIIB. The ELR cut-off point used in this study was 0.05 (AUC: 0.388) which differentiated between High and Low ELR. The subtype percentage of breast cancer in Luminal A, Luminal B, Her-2, and TNBC (triple negative breast cancer) were 10%, 48.3%, 25%, and 16.7% respectively. Luminal type of the breast cancer patients was found 58.3% in group ELR ≥ 0.05, whereas non-luminal type was found 41,7% (OR: 3.375; CI95%: 1.348-8.448; P = 0.008). In addition, there was no significant relationship between clinical stadium, Ki-67, histopathological grading, and TNM with ELR in breast cancer (P < 0.05).
There was a significant relationship between ELR and subtype of breast cancer patient at Sanglah Hospital, Bali, Denpasar, Indonesia. However, further study needs to be conducted to any variables that did not show a significant relationship. In addition, further studies with bigger sample size are necessary to learn the cause behind the peculiar results.
Clinical trial identification
Legal entity responsible for the study
Udayana University, Sanglah General Hospital, Bali, Indonesia.
Has not received any funding.
All authors have declared no conflicts of interest.