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Poster display - Cocktail

905 - Dose distribution in coronary arteries in left-sided breast cancer treated with Radiotherapy

Date

24 Nov 2018

Session

Poster display - Cocktail

Presenters

Umesh Velu

Citation

Annals of Oncology (2018) 29 (suppl_9): ix8-ix12. 10.1093/annonc/mdy427

Authors

U. Velu1, P.S. Alurkar2

Author affiliations

  • 1 Radiation Oncology, Kasturba Medical College, 576104 - Manipal/IN
  • 2 Radiotherapy, Kasturba Medical College, 576104 - Manipal/IN
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Resources

Abstract 905

Background

RT in left-sided breast cancer can lead to an increased risk of coronary artery disease (CAD). The type of RT technique and volumes, use of systemic therapy and patient related factors determine the risk of CAD. However, these cardiac events do not manifest until 10 years after RT.

Methods

We contoured the coronary artery segments in women with left-sided breast cancer and analyzed the dose distribution parameters. The mean and maximum doses for the segments of coronary arteries were noted in 15 such patients who underwent adjuvant RT (42.5 Gy in 16 fractions). All the patients were treated by 3DCRT with standard two-field tangential RT technique, with or without a supraclavicular field.

Results

Whole heart dose may not be the best predictor of all types of radiation induced heart disease. It was observed that the maximum and mean dose to the coronary arteries was 26.4 Gy and 8.8 Gy respectively. This predicts the average risk of coronary artery disease.

Conclusions

RT to the left chest wall can expose patients to an increased risk of CAD and there seems to be an association between the location of the RT beam and the location of the coronary events. Hence, radiation oncologists should utilize the tools and techniques available to reduce doses to cardiovascular structures.

Editorial acknowledgement

Clinical trial identification

Legal entity responsible for the study

Umesh Velu.

Funding

Has not received any funding.

Disclosure

All authors have declared no conflicts of interest.

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