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Poster display - Cocktail

1175 - Association of Serum Vitamin D Level and Vitamin D Receptor Polymorphism (Apa 1) And Breast Cancer

Date

24 Nov 2018

Session

Poster display - Cocktail

Presenters

Suzy Gohar

Citation

Annals of Oncology (2018) 29 (suppl_9): ix1-ix7. 10.1093/annonc/mdy426

Authors

S.F. Gohar1, S. Al-Hassanin1, B. Montaser2, S. Soliman3

Author affiliations

  • 1 Oncology, Faculty of Medicine - Menoufia University, 32511 - Shebin El Kom/EG
  • 2 Clinical Pathology, Faculty of Medicine - Menoufia University, 32511 - Shebin El Kom/EG
  • 3 Public Health And Community Medicine, Faculty of Medicine - Menoufia University, 32511 - Shebin El Kom/EG
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Resources

Abstract 1175

Background

The active form of vitamin D (1,25-dihydroxyvitamin D3) is thought to be protective against breast cancer. The activity of this steroid hormone is mediated mainly through the vitamin D receptor (VDR). Studies suggest that in case of vitamin D deficiency or VDR gene polymorphisms, vitamin D responses are altered and may be involved in the risk of breast cancer.

Methods

This case control study was conducted at clinical oncology and clinical pathology departments, in faculty of medicine, Menoufia University. A total of 114 participants (60 patients and 54 healthy participants) were included. Vitamin D levels and Apa1 polymorphism were assessed in both patients and healthy controls.

Results

Mean serum vitamin D levels were significantly higher among normal controls compared to cancer patients (31.54 ± 4.57 versus 14.12 ± 1.43) respectively (P value <0.001).in relation to Apa1 gene the serum vitamin D levels were significantly associated with AA and AC genotypes (P value<0.001) and both of these genotypes were prevalent in breast cancer compared to CC genotype. The serum vitamin D levels were lower in patients with larger tumor size, lymph node involvement, advanced stage, metastatic disease, in patients with capsular and lympho-vascular invasion. Low vitamin D levels and AC genotypes were significantly related to Her 2 positive disease.

Conclusions

Vitamin D level was significantly lower in breast cancer patients and was related to Apa 1 AA and AC genotypes both genotypes are associated with breast cancer risk. Testing the effect of varying genotypes on the function of the VDR and vitamin D status could help to improve future testing and treatment of woman at risk for breast cancer.

Editorial acknowledgement

Clinical trial identification

Legal entity responsible for the study

The authors.

Funding

Has not received any funding.

Disclosure

All authors have declared no conflicts of interest.

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