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Poster display - Cocktail

1456 - Anticancer activity of Moringa Oliefera mediated Silver Nanoparticles (AgNps) on Human Lymphocyte Cells

Date

24 Nov 2018

Session

Poster display - Cocktail

Presenters

S Mahalakshmi

Citation

Annals of Oncology (2018) 29 (suppl_9): ix23-ix27. 10.1093/annonc/mdy430

Authors

S. Mahalakshmi

Author affiliations

  • Nanoscience And Technology, Bharathiar University, 641046 - Coimbatore/IN
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Resources

Abstract 1456

Background

Silver nanoparticles (AgNPs) have now been recognized as promising therapeutic molecules and are extending their use in cancer diagnosis and therapy. In the present study, the green synthesis of silver nanoparticles (AgNPs) from aqueous solution of silver nitrate (AgNO3) by using Moringa Oliefera leaf extract has been reported. Moringa Oliefera is a medicinal compound. Specific components of Moringa preparations that have been reported to have hypotensive, anticancer, and antibacterial activity include 4-(4'-O-acetyl-α-L-rhamnopyranosyloxy)benzyl isothiocyanate, 4-(α-L-rhamnopyranosyloxy)benzyl isothiocyanate, niazimicin, pterygospermin, benzyl isothiocyanate, and 4-(α-L-rhamnopyranosyloxy) benzyl glucosinolate.

Methods

Silver nanoparticles (AgNPs) were prepared by an eco-friendly chemical reduction method using a Moringa Oliefera plant extract solution as both a reducing and stabilizing agent. This study deals with the cytotoxicity of silver nanoparticles (AgNPs) on human lymphocytes isolated from peripheral blood. Human lymphocytes were treated with different amounts (2 or 10 ×10³ NPs/cell) of AgNPs for 24hs.

Results

Silver nanoparticles (AgNPs) were characterized by UV–Visible absorption spectroscopy with an intense surface plasmon resonance band at 410 nm which reveals the formation of nanoparticles. Fourier transmission infrared spectroscopy (FTIR) showed that nanoparticles were capped with plant compounds. Field Emission Scanning Electron Microscopy (FESEM) showed silver nanoparticles, with a size of 61 nm, were spherical. The X-ray diffraction spectrum (XRD) pattern clearly indicates that AgNPs formed in the present synthesis were crystalline and cubic in nature. In addition, these biologically synthesized nanoparticles were also proved to exhibit excellent cytotoxic effect on a human lymphocyte cells. These results indicated that AgNPs can be effectively utilized in pharmaceutical, biotechnological and biomedical applications.

Conclusions

Anticancer activity of the biosynthesized AgNPs may be due to the presence of alkaloids present in the Moringa Oliefera Leaf extract. However, it necessitates clinical studies to as certain their potential as Anticancer Agents.

Editorial acknowledgement

Clinical trial identification

Legal entity responsible for the study

Dr.P.P.Vijaya, Associate Professor, Department of Nanoscience and Technology, Bharathiar University, Coimbatore, India.

Funding

Has not received any funding.

Disclosure

The author has declared no conflicts of interest.

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