Oops, you're using an old version of your browser so some of the features on this page may not be displaying properly.

MINIMAL Requirements: Google Chrome 24+Mozilla Firefox 20+Internet Explorer 11Opera 15–18Apple Safari 7SeaMonkey 2.15-2.23

Poster lunch

985 - Genetic Association of Matrix metalloproteinase MMP- 1, MMP-3 and MMP-9 Genes with HCV-related Hepatocellular Carcinoma in Egyptian patients (48P)


18 Nov 2017


Poster lunch


Translational Research;  Hepatobiliary Cancers


Alshimaa Alhanafy


Annals of Oncology (2017) 28 (suppl_10): x7-x15. 10.1093/annonc/mdx653


A.M. Alhanafy1, B. Montaser2, W. Fathy2, N. Elabd3, S. Tayel4

Author affiliations

  • 1 Department Of Clinical Oncology And Nuclear Medicine, Menoufia University , Faculty of Medicine, 32511 - Shebin El Kom/EG
  • 2 Department Of Clinical Pathology, Menoufia University , Faculty of Medicine, 32511 - Shebin El Kom/EG
  • 3 Department Of Tropical Medicine, Menoufia University , Faculty of Medicine, 32511 - Shebin El Kom/EG
  • 4 Department Of Medical Biochemistry, Menoufia University , Faculty of Medicine, 32511 - Shebin El Kom/EG


Abstract 985


Hepatocellular carcinoma (HCC) is one of the most frequent cancers in Egypt in which there is high prevalence of hepatitis C virus (HCV) infection. Matrix metalloproteinases (MMPs) are multifunctional proteins that assume an urgent part in cell development, differentiation, inflammation and angiogenesis. MMPs gene polymorphism might be included in development of HCV-related HCC. The study expected to explore relationship of MMP-1,3 & 9 genes polymorphisms with liver cirrhosis and HCC patients.


This study included 128 individuals who were enrolled from Menoufia University Hospital in the period between October 2015 and August 2016 classified into the following; Group I: included 48 patients with HCC on top of liver cirrhosis, they were 26 males and 22 females with mean age (58.60±5.29); Group II: 50 patients with liver cirrhosis, they were 26 males and 24 females with mean age (56.74±5.21); and Group III: 30 healthy subjects as controls, they were 15 males and 15 females with mean age (56.30 ±7.30). Diagnosis of HCC was done by their characteristic features in two imaging methods (abdominal US & triphasic CT). All subjects except controls were positive for serum HCV RNA. Liver functions tests, AFP & CHILD score were assessed. Genes polymorphisms were made by PCR-RFLP.


HCC patients had higher mutant G2G2 (35.4%) and G2 allele (62.5%) of MMP-1 gene than both cirrhotic (P 


MMP-1, 3, 9 gene mutation may be embroiled in progression of liver cirrhosis and hazard relationship for HCC development.

Clinical trial identification

Legal entity responsible for the study

Menoufia University




All authors have declared no conflicts of interest.

This site uses cookies. Some of these cookies are essential, while others help us improve your experience by providing insights into how the site is being used.

For more detailed information on the cookies we use, please check our Privacy Policy.

Customise settings
  • Necessary cookies enable core functionality. The website cannot function properly without these cookies, and you can only disable them by changing your browser preferences.