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Poster lunch

1932 - Early drop of LV ejection fraction can predict trastuzumab-related cardiotoxicity in patients with breast cancer (63P)

Date

18 Nov 2017

Session

Poster lunch

Topics

Cytotoxic Therapy;  Supportive Care and Symptom Management;  Breast Cancer

Presenters

Jinhyun Cho

Citation

Annals of Oncology (2017) 28 (suppl_10): x16-x24. 10.1093/annonc/mdx655

Authors

J. Cho1, E.K. Kim2, K.H. Yoo3, H. Lee4, H.K. Kim4, M.H. Heo5, J. Park1, J.S. Ahn4, Y. Im4, Y.H. Park4

Author affiliations

  • 1 Hematology-oncology, Inha University Hospital, 22332 - Incheon/KR
  • 2 Cardiology, Samsung Medical Center, 06351 - Seoul/KR
  • 3 Hematology-oncology, Gil Medical Center, 22332 - Incheon/KR
  • 4 Division Of Hematology-oncology, Department Of Medicine, Samsung Medical Center, 06351 - Seoul/KR
  • 5 Hematology-oncology, Keimyung University Dongsan Medical Center, 41931 - Daegu/KR
More

Resources

Abstract 1932

Background

While concerns about trastuzumab-related cardiac dysfunction (TRCD) in patients with breast cancer (BRCA) increasing, there is a lack of evidences to support current recommendation to monitor TRCD. Especially, in Asian population, clinical manifestations and predictors of TRCD were unknown. Therefore, we aimed to identify characteristics and predictors of TRCD in Asian patients with BRCA.

Methods

From 2003 to 2016, consecutive 1371 patients who treated with adjuvant trastuzumab for BRCA were enrolled. We excluded patients with metastatic BRCA, number of trastuzumab administration 10% in left ventricular ejection fraction (LVEF), with a decline below the normal limit value (50%). Median follow-up duration was 54.2 months.

Results

Of 787 patients evaluated (mean age, 50.3±9.5 years), 58 (7.4%) were developed TRCD (median time to develop TRCD, 6.1 [3.1-7.9] months) and most of them (75.9%) were improved from TRCD after 5.7 (3.5-17.7) months. TRCD patients had higher baseline blood pressure (SBP, mmHg; 125 [107-136] vs 114 [104-126], p = 0.005 and DBP, mmHg; 72 [65-81] vs 68 [61-76], p = 0.004), lower initial LVEF (63 [59-66] % vs 65 [61-68] %, p = 0.016) and more frequently administered anthracycline (98% vs 89%, p = 0.022). Cumulative dose of anthracycline was also higher in those with TRCD (404 [374-458] mg vs 372 [336-400] mg, p 5% within 3 months regardless of absolute LVEF value was more frequent in TRCD patients (78.3% vs 38.4%, p 5% within 3 months from trastuzumab administration was significantly associated with development of TRCD (HR, 45.1[17.0-127.6], p 

Conclusions

Asian BRCA patients received adjuvant trastuzumab were relatively young and less frequently developed TRCD compared to Western data. LVEF drop >5% within 3 months from trastuzumab administration was a strong predictor of TRCD.

Clinical trial identification

Legal entity responsible for the study

Yeon Hee Park

Funding

None

Disclosure

All authors have declared no conflicts of interest.

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