Oops, you're using an old version of your browser so some of the features on this page may not be displaying properly.

MINIMAL Requirements: Google Chrome 24+Mozilla Firefox 20+Internet Explorer 11Opera 15–18Apple Safari 7SeaMonkey 2.15-2.23

Poster lunch

1896 - Can Sentinel Lymph Node Biopsy Be Omitted in Patients With Clinical Node Negative Before Neoadjuvant Chemotherapy. (75P)


18 Nov 2017


Poster lunch


Breast Cancer


Takuto Yoshida


Annals of Oncology (2017) 28 (suppl_10): x16-x24. 10.1093/annonc/mdx655


T. Yoshida1, A. Yoshida1, N. Hayashi2, H. Yamauchi1

Author affiliations

  • 1 Breast Surgery, St. Luke's International Hospital, 104-8560 - Tokyo/JP
  • 2 Breast Surgical Oncology, St Luke’s International Hospital, 1048560 - Tokyo/JP


Abstract 1896


Recently minimum axillary surgery has been indicated due to its morbidity. Since the report of Z011, there is a change in axillary management, and even if metastasis is proven in Sentinel node biopsy (SNB), the patients whose axillary dissection is omitted are increasing. If a patient who SNB is unnecessary can be found before surgery, it can be possible to treat the patient more generously. We retrospectively reviewed the patients in which neo adjuvant chemotherapy (NAC) was performed with clinically N0 (cN0) and SNB was performed, and examined clinicopathological factors whether we can find patients who do not need even SNB biopsy.


A retrospective cohort study of cN0 breast cancer patients before NAC and who underwent breast surgery was conducted, investigating 199 consecutive patients between 2009 and 2015 in our hospital. Institutional review board approved this retrospective study. Between the patients with or without nodal metastasis in SNB after NAC, we compared the differences in clinicopathological factors including Estrogen Receptor (ER), Progesterone Receptor (PgR), human epidermal growth factor receptor 2 (HER2), nuclear grade(NG), Ki-67 in needle biopsy specimens, and tumor size before NAC, and complete response on MRI (MRI-CR) after NAC. We defined MRI-CR as no residual enhancement, or non-invasive faint and indistinct enhancement.


Of the 199 patients, 184 patients (92%) were pathological node negative and 15 patients (8%) are node positive after NAC. In univariate analysis, patients achieved MRI-CR (p 


Detection of MRI-CR in patient with cN0 before NAC correlate no nodal metastasis in SNB. In such patient, there is a possibility that SNB might be omitted in the future.

Clinical trial identification

Legal entity responsible for the study

St Luke\'s International Hospital




All authors have declared no conflicts of interest.

This site uses cookies. Some of these cookies are essential, while others help us improve your experience by providing insights into how the site is being used.

For more detailed information on the cookies we use, please check our Privacy Policy.

Customise settings
  • Necessary cookies enable core functionality. The website cannot function properly without these cookies, and you can only disable them by changing your browser preferences.