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1783 - Blood neutrophil-to-lymphocyte ratio is associated with prognosis in advanced gastrointestinal stromal tumors (GIST) treated with imatinib (484O)


18 Nov 2017




Cytotoxic Therapy;  GIST


Piotr Rutkowski


Annals of Oncology (2017) 28 (suppl_10): x149-x152. 10.1093/annonc/mdx675


P. Rutkowski1, P. Teterycz1, A. Klimczak1, E. Bylina2, K. Szamotulska3, I. Lugowska1

Author affiliations

  • 1 Soft Tissue/bone Sarcoma And Melanoma, Maria Sklodowska-Curie Institute - Oncology Center, 02781 - Warsaw/PL
  • 2 Clinical Trial Unit, Maria Sklodowska-Curie Institute - Oncology Center, 02781 - Warsaw/PL
  • 3 Biostatistics, Institute of Mother and Child, Warsaw/PL


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Abstract 1783


Neutrophil-to-lymphocyte ratio (NLR) was shown to be prognostic in several solid malignancies. There are limited data about predictive/prognostic value of NLR during targeted therapy of patients with advanced gastrointestinal stromal tumors (GIST). The aim of the study was to asses a clinical value of this ratio in patients with advanced GIST.


Between 2001 and 2016, 385 patients with metastatic/unresectable GIST treated initially with imatinib were included to the analysis. In all patients the NLR was assessed at the baseline, after 3 months of treatment and upon disease progression (or last observation). The cut off for NLR was set at 2.7. Kaplan-Meier survival probability estimation with in log-rank test, and Cox's proportional hazards model were used for analysis.


Median Progression-Free Survival (PFS) on imatinib treatment was 44.8 months, 5-year rate 43%; median Disease Specific Survival (DSS) – 87.2 months, 10-year rate 36.3%. NLR >2.7 at baseline was significantly associated with poorer OS and DSS: median DSS was 89.3 months (95%CI 80.2-115) for NLR ratio ≤2.7 vs. 59.4 months (95%CI 48.6-82) for NLR >2.7 (p 


Our results demonstrate the usefulness of NLR as a prognostic and predictive marker as well as marker for treatment monitoring in patients with advanced GIST treated with imatinib.

Clinical trial identification

Legal entity responsible for the study

Maria Sklodowska-Curie Institute - Oncology Center, Warsaw, Poland




P. Rutkowski: I have received honoraria for lectures from Novartis, Roche, Pfizer, BMS, MSD and served as a member of Advisory Board for Novartis, Merck, Amgen, Blueprint, Roche, BMs and MSD.

All other authors have declared no conflicts of interest.

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