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Poster lunch

1240 - The Role of Neuropeptide Y in Cancer-Associated Anorexia and its Correlation with Interleukin-1 Beta (511P)

Date

18 Nov 2017

Session

Poster lunch

Presenters

Irza Wahid

Citation

Annals of Oncology (2017) 28 (suppl_10): x155-x165. 10.1093/annonc/mdx676

Authors

I. Wahid

Author affiliations

  • Division Of Hematology And Medical Oncology, Internal Medicine, Dr. M. Djamil General Hospital, 25127 - Padang/ID
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Resources

Abstract 1240

Background

Anorexia has been known as a factor that can increase mortality and morbidity in cancer patients. Anorexia in cancer patients can be triggered by the cytokines which produced by tumor cells and cells that involved in immunological response to the tumor. One of that cytokines is interleukin-1 Beta (IL-1β). Neuropeptide Y (NPY) is an extremely powerful orexigenic peptide that stimulates energy deficiency as a hunger center and proopiomelanocortin (POMC) is an anorexigenic peptide for satiety. Cytokines produced by tumor cells inhibit NPY in the orexigenic pathway and excite the POMC on the anorexigenic pathway caused anorexia. In cancer, the most important process causes anorexia is inhibition of NPY.

Methods

This study is an observational analytic with a cross-sectional approach. The research was conducted at Dr. M. Djamil Hospital. The sample of this study was all patients with cancer-associated anorexia who were treated in the Hematology and Medical Oncology Division, Internal Medicine Department of Dr. M. Djamil Hospital. Sample is a patient who satisfies the inclusion criteria taken consecutively (n = 30).

Results

This study found the average levels of NPY in patients with cancer-associated anorexia is 2.11 ± 0.76 pg/ml. It is significantly lower than normal limit (5-90 pg/ml) (p 

Conclusions

The result of the study concludes that there is a decrease the average levels of NPY and increase the average levels of IL-1β in patients with cancer-associated anorexia, and there is a negative correlation between the levels of IL-1β and NPY levels in patients with cancer-associated anorexia.

Clinical trial identification

Legal entity responsible for the study

Division of Hematology and Medical Oncology, Internal Medicine Department, Dr. M. Djamil General Hospital, Padang, Indonesia.

Funding

None

Disclosure

All authors have declared no conflicts of interest.

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