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Poster lunch

1514 - SPARCL1, a novel prognostic predictive factor for GI malignancies: a meta-analysis (32P)

Date

18 Nov 2017

Session

Poster lunch

Presenters

Hanguang Hu

Citation

Annals of Oncology (2017) 28 (suppl_10): x7-x15. 10.1093/annonc/mdx653

Authors

W. Cai, H. Hu, W. Ge

Author affiliations

  • Department Of Medical Oncology, 2nd Affiliated Hospital of Zhejiang University University School of Medicine, 310009 - Hangzhou/CN
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Resources

Abstract 1514

Background

Secreted protein acidic and rich in cysteines-like 1 (SPARCL1) is abnormally expressed in gastrointestinal (GI) malignancies. However, the correlation between SPARCL1 expression and the prognosis of patients remains unknown. Therefore, we performed a meta-analysis to investigate the potential value of SPARCL1 as a prognostic predictive marker for GI malignancies.

Methods

The PubMed, Embase, EBSCO, CNKI, and Wanfang databases were systematically searched for studies examining SPARCL1 and clinicopathological features, including the prognoses of patients. Hazard ratios (HRs) and odds ratios (ORs) from individual studies were calculated and pooled using a random-effects or fix-effects model. Heterogeneity and publication bias analyses were performed.

Results

Data from 8 studies, including a total of 2,356 patients, were summarized. The expression of SPARCL1 suggested a better prognosis (HR = 0.57, 95% CI: 0.445-0.698, P = 0.000) and was associated with clinicopathological features of GI malignancies, including distant metastasis (OR = 0.44, 95% CI: 0.23-0.85, P = 0.014), lymph node metastasis (OR = 0.56, 95% CI: 0.39–0.81, P = 0.002) and tumor differentiation (OR = 2.21, 95% CI: 1.82–2.69, P = 0.000). Subgroup analyses based on cancer type revealed that the expression of SPARCL1 had no effect on lymph node metastasis in colorectal cancer, and it did not influence tumor differentiation in gastric cancer. (all P > 0.05).

Conclusions

SPARCL1 could be a novel prognostic predictive factor for GI malignancies. The expression of SPARCL1 could influence the clinicopathological features of GI malignancies. Further large-scale studies are essential to confirm SPARCL1’s prognostic predictive value, and more fundamental experimental studies are needed to illustrate the mechanisms.

Clinical trial identification

Legal entity responsible for the study

Hanguang HU

Funding

None

Disclosure

All authors have declared no conflicts of interest.

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