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Poster lunch

807 - Prevalence and genotyping of HPV Infection in Jiangsu, a High-Risk Region of Esophageal Cancer from China (3P)

Date

18 Nov 2017

Session

Poster lunch

Presenters

Yan Miao

Citation

Annals of Oncology (2017) 28 (suppl_10): x1-x6. 10.1093/annonc/mdx652

Authors

Y. Miao, R. Liu, Y. Pu, L. Yin

Author affiliations

  • School Of Public Health, Southeast University, 210009 - Nanjing/CN
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Resources

Abstract 807

Background

An increasing number of studies have found HPV infection in esophageal carcinoma patients recently. However, reported rates of HPV infection as evidenced were divergent by differences in geographic regions of sample origin.

Methods

To detect the HPV status in Huai’an, China, a high-risk area for esophageal cancer (EC), ELISA was used to determine the seropositivity of HPV16/18 in the blood plasma of the high-risk population of Huai’an esophageal cancer. In the high-risk group, 937 volunteers were recruited by cluster sampling from high incident counties for esophageal cancer in Jiangsu during 2009 to 2013. For the patient group, HPV L1 DNA and HPV genotypes were identified in the cancerous tissues of 105 EC patients from the First People's Hospital in Huai’an by nested-PCR and dot blot hybridization.

Results

The results showed that the overall rate of HPV infection in the high-risk group and the patient group was 31.4% and 34.36%, respectively. HPV18/16 covered 77.3% of HPV infection among the high-risk group. In the EC patient group, only HPV18 was detected in cancerous tissues, and the prevalence of infection (24.2%) was integrally higher than most related reports in other areas.

Conclusions

In conclusion, the current study evaluates the prevalence and genotyping of HPV infection in a high-risk population and patients with esophageal cancer in Huai’an, Jiangsu, and HPV18 may be the highest risk subtype of HPV infection in the Jiangsu area.

Clinical trial identification

Legal entity responsible for the study

School of Public Health, Southeast University

Funding

The National Science Foundation of China

Disclosure

All authors have declared no conflicts of interest.

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