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Basic science

1193 - Predictive value of the improvement in tumor microenvironment for progression in breast cancer patients treated with neoadjuvant chemotherapy (543O)

Date

17 Nov 2017

Session

Basic science

Presenters

Wataru Goto

Citation

Annals of Oncology (2017) 28 (suppl_10): x170-x172. 10.1093/annonc/mdx678

Authors

W. Goto1, S. Kashiwagi1, Y. Asano1, K. Takada1, K. Takahashi2, S. Noda1, T. Takashima1, N. Onoda1, S. Tomita2, K. Hirakawa1, M. Ohira3

Author affiliations

  • 1 Surgical Oncology, Osaka City University Medical School, 545-8585 - Osaka/JP
  • 2 Pharmacology, Osaka City University Medical School, 545-8585 - Osaka/JP
  • 3 Surgical Oncology, Osaka City University Graduate School of Medicine, 545-8585 - Osaka/JP
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Abstract 1193

Background

Tumor-infiltrating lymphocytes (TILs) can be used to monitor the immune response, and are important in predicting treatment responses and outcomes for various types of cancer. In this study, we evaluated the prognostic significance of CD8+ TILs and FOXP3+ TILs before and after neoadjuvant chemotherapy (NAC).

Methods

Except for patients who achieved pathological complete response, 136 breast cancer patients treated with NAC were examined. CD8+ TILs and FOXP3+ TILs in biopsy specimens and residual tumors were evaluated by immunohistochemistry. CD8+ TILs and FOXP3+ TILs status was assessed, and the rates of their changes before and after NAC were calculated.

Results

All patients with high rates of changes in the CD8+ TILs or low rates of changes in the FOXP3+ TILs or high rates of changes in the CD8/FOXP3 ratio (CFR) had significantly better recurrence-free survival (RFS) (P = 0.006, P = 0.044, P 

Conclusions

Improvement in immune microenvironment following NAC has a relationship with good outcome. In particular, rates of changes in the CFR may be a useful biomarker to predict prognosis of patients treated with NAC in all breast cancer subtypes.

Clinical trial identification

Legal entity responsible for the study

Shinichiro Kashiwagi

Funding

None

Disclosure

All authors have declared no conflicts of interest.

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