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Poster lunch

1518 - Platinum based chemotherapy induced fatigue among cancer patients (567P)


18 Nov 2017


Poster lunch




Annals of Oncology (2017) 28 (suppl_10): x177-x182. 10.1093/annonc/mdx668


S. Modak1, H. Singh1, R.P. Singh2, A. Mukhopadhyay3

Author affiliations

  • 1 Pharmacology, Guru Gobind Singh Medical College & Hospital, 151203 - Faridkot/IN
  • 2 Radiation Oncology, Guru Gobind Singh Medical College & Hospital, 151203 - Faridkot/IN
  • 3 Urology, Guru Gobind Singh Medical College & Hospital, 151203 - Faridkot/IN


Abstract 1518


Though cancer patients are treated with care, abiding by standard treatment guidelines, majority have post treatment symptoms. In developing countries like India, cancer treatment related symptoms & their interference with quality of life (QOL) are often overlooked. Fatigue is one of the most common & disruptive symptom experienced by cancer survivors treated with platinum based chemotherapy (PBC). Although emesis is a well-established symptom due to PBC, evidence is very limited by self-report measures regarding fatigue. Thus the aim of this study was to assess the PBC induced fatigue in cancer survivor patients.


This cross-sectional observational study was conducted in a tertiary care hospital in Punjab, India. A total number of 53 Genitourinary & 31 Breast cancer patients were recruited among them 39 were treated with PBC in genitourinary group only. Before inclusion of patients other causes of fatigue e.g. anaemia, liver dysfunction and azotemia have been ruled out. MD Anderson symptom inventory cancer fatigue module was used to assess general symptoms including fatigue & its interference with QOL. Chi-square 2 tailed test with Yates correction was used to compare fatigue in between genitourinary group (PBC versus non PBC) as well as between genitourinary and breast cancer group to confirm that the fatigue is not due to the cancer alone.


In comparison to breast cancer (without PBC) group, fatigue score was significantly higher in genitourinary cancer (with PBC) group with p value 0.0001. Fatigue score was also significantly higher in PBC treated genitourinary group than non PBC treated genitourinary group with p value 0.004, but there was no significant difference in QOL among different groups.Table: 567P

Group variablesTotal no of patientSignificance (chi- square test)
Inter-group comparison: Genitourinary Breast39 31p = 0.001
Intra-group comparison: Genitourinary with PBC Genitourinary without PBC39 14p = 0.004


Though emesis is the most focused & well established treatment related symptom of PBC, fatigue is also an important cornerstone which needs proper care & preventive measure. Further study with large number of patients in each treatment group is required to substantiate these findings

Clinical trial identification

Not applicable.

Legal entity responsible for the study





All authors have declared no conflicts of interest.

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