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Poster lunch

1872 - Micro-RNA down express ABCG2 gene in Adjuvant Chemotherapy in Female Breast Cancer (561P)

Date

18 Nov 2017

Session

Poster lunch

Presenters

Samen Saeed

Citation

Annals of Oncology (2017) 28 (suppl_10): x173-x176. 10.1093/annonc/mdx679

Authors

S. Saeed1, M.N. Faisal1, W. Majeed1, J. Hussain1, H. Muzaffar1, A. Mahmood2, H. Javed1

Author affiliations

  • 1 Institute Of Pharmacy,physiology And Pharmacology, University of agriculture, Faisalabad, 38040 - Faisalabad/PK
  • 2 Institute Of Pharmacy, Physiology & Pharmacology, University of Agriculture, Faisalabad, 38040 - Faisalabad/PK
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Resources

Abstract 1872

Background

Cancer is a group of the devastating disease having worldwide distribution, characterized by persistent proliferation or regeneration of cells. Breast cancer is a type of cancer that involves breast tissue and is one of the leading causes of deaths in women.

Methods

The current study was designed to determine the expression level of BCRP encoded by ABCG2 gene has a central role in the pharmacokinetics of both xenobiotic and drugs as well as contributes to multidrug resistance in cancer therapy. Quantitative real-time PCR was used to determine the gene expression level and analysis.

Results

The expression level of micro-RNA in up regulation of breast cancer resistance gene was determined as well as Foxo is playing a key role. Results showed that the relative Mir 140, Mir 145 and Micro 328 genes expression level are significantly higher expression level in breast cancer patient which down-regulate the ABCG protein. Src and mTOR genes are highly expressed in breast cancer patient. The data was analyzed statistically by using ANOVA and DMR test for significance.

Conclusions

Results concluded that higher expression of microRNA, mTor and FOXO down regulate the ABCG2 gene and stimulate the process of chemo-resistance, cell proliferation, apoptosis resistance.

Clinical trial identification

Legal entity responsible for the study

Ethical Review Committee, Punjab Medical College, Faisalabad.

Funding

None

Disclosure

All authors have declared no conflicts of interest.

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