Oops, you're using an old version of your browser so some of the features on this page may not be displaying properly.

MINIMAL Requirements: Google Chrome 24+Mozilla Firefox 20+Internet Explorer 11Opera 15–18Apple Safari 7SeaMonkey 2.15-2.23

Poster lunch

1719 - Is there a link between BRCA1 and BRCA2 mutations and obesity, high blood pressure and diabetes mellitus in Romanian high-risk breast cancer cases? (16P)

Date

18 Nov 2017

Session

Poster lunch

Presenters

Nicoleta Antone

Citation

Annals of Oncology (2017) 28 (suppl_10): x1-x6. 10.1093/annonc/mdx652

Authors

N. Antone1, L. Pop2, E. Dronca2, A. Stoian1, R. Matei1, M. Ligtenberg3, H. Ouchene3, A. Onisim1, O. Rotaru1, R. Eniu4, A. Eniu1

Author affiliations

  • 1 Breast Cancer Department, Ion Chiricuta Oncology Institute-IOCN, 400015 - Cluj-Napoca/RO
  • 2 Research Center For Functional Genomics (rcfg), Biomedicine And Translational Medicine, Iuliu Hatieganu University of Medicina and Pharmacy, Cluj-Napoca/RO
  • 3 Department Of Human Genetics, Radboud University Medical Center, Nijmegen/NL
  • 4 School Of Medicine, Cardiff University School of Medicine, Cardiff/GB
More

Resources

Abstract 1719

Background

A systematic analysis to determine the frequency of obesity, high blood pressure (HBP) and diabetes mellitus (DM) for high-risk breast cancer(BC) patients (pts) BRCA1/2 (B1, B2) mutated vs pts without B1/B2 mutations.

Methods

This prospective study evaluated 44 pts with B1/B2 pathogenic mutations vs 191 non-mutated high-risk BC pts, tested in IOCN during 2015-2016. Inclusion criteria: triple negative BC 

Results

Out of 44 BC pts, 29 (11.6%) pts B1 mutated, 15 (6%) pts B2 and 191 pts had no B1/B2 deleterious mutations. The median age at diagnosis was 39 yo (28-74) in the B1/B2 mutated group and 37 yo (23- 80) for pts without B1/B2 mutations, p = 0.1122. In B1/B2 mutated pts, 22(50%) had normal weight, 13(29.54%) were overweight and 9 (20.45%) were obese. In the non-mutated group 4 (2.11%) pts were underweight, 114 (60.31%) had normal weight, 49(25.92%) pts were overweight and 22(11.64) were obese, p = 0.0742. Regarding HBP, in the B1/B2 mutated, 9 (20.45%) pts presented the condition in their personal history, while 35(79.54%) had no history of HBP, and in the non-mutated group, 15 (7.98%) pts related history of HBP and 173 (92.02%) pts did not have HBP, p = 0.0246, statistically significant when comparing the subgroups. In the B1/B2 mutated group, only 1 (2,27) patient related DM as comorbidities, while 43(97.23%) pts did not present the disease vs 5(2. 80%) pts with DM and 174 (97.20%) pts who did not have DM in the non- mutated group, p = 0.9999.

Conclusions

This prospective study represents the first analysis of conditions such as obesity, HBP and DM in Romanian high-risk BC pts. Our results indicate that HBP is a more frequent comorbidity in Romanian high risk BC B1/B2 mutated pts when compared with pts without B1/B2 deleterious mutations.

Clinical trial identification

NCT02317120.

Legal entity responsible for the study

Alexandru Eniu

Funding

International Innovation Grant-Conquer Cancer Foundation

Disclosure

All authors have declared no conflicts of interest.

This site uses cookies. Some of these cookies are essential, while others help us improve your experience by providing insights into how the site is being used.

For more detailed information on the cookies we use, please check our Privacy Policy.

Customise settings