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Poster lunch

1305 - Incidence of hypothyroidism in patients treated for carcinoma breast with incidental radiation dose to thyroid gland treated with different fractionation and correlation of these doses with thyroid function test (60P)

Date

18 Nov 2017

Session

Poster lunch

Presenters

NIVEDITA SARKAR

Citation

Annals of Oncology (2017) 28 (suppl_10): x16-x24. 10.1093/annonc/mdx655

Authors

N. SARKAR, H.B. Govardhan

Author affiliations

  • Radiation Oncology, KIDWAI Memorial Institute of oncology, 560029 - Bangalore/IN
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Resources

Abstract 1305

Background

Hypothyroidism is common following radiotherapy in patients with head & neck tumors. The association between radiotherapy and hypothyroidism in breast cancer patients has been investigated in only few studies. On the other hand, radiation exposure to parts of the thyroid gland seems unavoidable in breast cancer patients receiving radiotherapy to the ipsilateral supraclavicular fossa. Studies reveal that hypothyroidism is related to volume of thyroid gland and dose received. This study is taken up to find such correlation between volume of thyroid and thyroid function test.

Methods

A total of 83 patients treated with adjuvant radiation therapy in carcinoma breast were included. All patients were treated with 3DCRT. V20, V30, V40 and V50 calculated for all patients using standard DVH. Base line thyroid function test and clinical assessment was done before radiation therapy. All patients were treated with 50Gy in 25 fractions (Conventional arm) or 40Gy in 15 fractions (Hypo fractionated arm) to chest wall and SCF. After therapy, TFT and clinical evaluation were done at every 3 months interval for a year.

Results

Mean thyroid volume was found to be 10.3cc. Mean dose received by thyroid gland was 47.5Gy in Conventional arm and 38Gy in Hypo fractionated arm. The V20, V30, V40 and V50 of thyroid gland in the Conventional arm were 60.6, 56.5, 53.3 and 35.2%. Mean TSH change between baseline and 1 year was 40.9% in Conventional arm and 35.2% in Hypo fractionated arm.Table: 60P

n = 83Subclinical hypothyroidismClinical hypothyroidismTotal
Baseline (0 month)011
6TH month6612
Conventional arm (n = 43)538
Hypofractionated arm (n = 40)134
1 Year6915
Conventional arm (n = 43)459
hypofractionated Arm (n = 40)246

No significant correlation was observed with radiation dose to thyroid gland and thyroid function test. A significant correlation was noted with TSH level and thyroid volume in the 50Gy arm. Thyroid volume

Conclusions

In our study we did not find any significant correlation between thyroid radiation doses with the changes in TFT parameter. Patients who received conventional fractionation and with thyroid volume

Clinical trial identification

Legal entity responsible for the study

SELF

Funding

None

Disclosure

All authors have declared no conflicts of interest.

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