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Poster lunch

1876 - Higher expression of Micro-RNA and Wnt signaling cascade in RNASEL candidate gene in prostate cancer (562P)

Date

18 Nov 2017

Session

Poster lunch

Presenters

Irfanullah Hijazi

Citation

Annals of Oncology (2017) 28 (suppl_10): x173-x176. 10.1093/annonc/mdx679

Authors

I. Hijazi1, M.N. Faisal1, A. Mahmood1, H. Muzaffar2, H. Nazir1, J. Hussain2

Author affiliations

  • 1 Department Of Pharmacy, Physiology And Pharmacology, University of Agriculture, Faisalabad, 38040 - Faisalabad/PK
  • 2 Institute Of Pharmacy, Physiology & Pharmacology, University of Agriculture, Faisalabad, 38040 - Faisalabad/PK
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Resources

Abstract 1876

Background

Cancer is a heterogeneous disease with worldwide distribution and aberrant alterations in gene expression. Prostate cancer is the result of considerable mutation in genome that are expressed in epithelial cells of prostate gland.

Methods

Current study guide us to identify the tools for detection of mutational signature in prostate gland and identified gene expression patterns was directed for targeted medical therapy and exploring the role of micro RNA and Wnt signaling cascade. Quantitative real time PCR was performed to determine the gene expression level.

Results

Expression level of micro-RNA and Wnt signaling cascade in up regulation of RANSEL gene in prostate cancer was determined as well as FOXO is playing a key role. Results showed that the relative Mir 140, Mir 145 and Micro 328 genes expression level is significantly higher in prostate cancer patients which down regulate the FOXO 1 and FOXO 3 gene while as, TP53 expression is highly expressed in prostate cancer patients. The data was analyzed statistically by using ANOVA and DMR.

Conclusions

We concluded that Mir 140, Mir 145, Micro 328, FOXO 1, FOXO 3 and TP 53 genes expression level and Wnt signaling cascade play an important role in up regulation of RNASEL gene in prostate cancer.

Clinical trial identification

Legal entity responsible for the study

Ethical review Committee, Punjab Medical College, Faisalabad.

Funding

None

Disclosure

All authors have declared no conflicts of interest.

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