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Poster lunch

985 - Genetic Association of Matrix metalloproteinase MMP- 1, MMP-3 and MMP-9 Genes with HCV-related Hepatocellular Carcinoma in Egyptian patients (48P)

Date

18 Nov 2017

Session

Poster lunch

Presenters

Alshimaa Alhanafy

Citation

Annals of Oncology (2017) 28 (suppl_10): x7-x15. 10.1093/annonc/mdx653

Authors

A.M. Alhanafy1, B. Montaser2, W. Fathy2, N. Elabd3, S. Tayel4

Author affiliations

  • 1 Department Of Clinical Oncology And Nuclear Medicine, Menoufia University , Faculty of Medicine, 32511 - Shebin El Kom/EG
  • 2 Department Of Clinical Pathology, Menoufia University , Faculty of Medicine, 32511 - Shebin El Kom/EG
  • 3 Department Of Tropical Medicine, Menoufia University , Faculty of Medicine, 32511 - Shebin El Kom/EG
  • 4 Department Of Medical Biochemistry, Menoufia University , Faculty of Medicine, 32511 - Shebin El Kom/EG
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Resources

Abstract 985

Background

Hepatocellular carcinoma (HCC) is one of the most frequent cancers in Egypt in which there is high prevalence of hepatitis C virus (HCV) infection. Matrix metalloproteinases (MMPs) are multifunctional proteins that assume an urgent part in cell development, differentiation, inflammation and angiogenesis. MMPs gene polymorphism might be included in development of HCV-related HCC. The study expected to explore relationship of MMP-1,3 & 9 genes polymorphisms with liver cirrhosis and HCC patients.

Methods

This study included 128 individuals who were enrolled from Menoufia University Hospital in the period between October 2015 and August 2016 classified into the following; Group I: included 48 patients with HCC on top of liver cirrhosis, they were 26 males and 22 females with mean age (58.60±5.29); Group II: 50 patients with liver cirrhosis, they were 26 males and 24 females with mean age (56.74±5.21); and Group III: 30 healthy subjects as controls, they were 15 males and 15 females with mean age (56.30 ±7.30). Diagnosis of HCC was done by their characteristic features in two imaging methods (abdominal US & triphasic CT). All subjects except controls were positive for serum HCV RNA. Liver functions tests, AFP & CHILD score were assessed. Genes polymorphisms were made by PCR-RFLP.

Results

HCC patients had higher mutant G2G2 (35.4%) and G2 allele (62.5%) of MMP-1 gene than both cirrhotic (P 

Conclusions

MMP-1, 3, 9 gene mutation may be embroiled in progression of liver cirrhosis and hazard relationship for HCC development.

Clinical trial identification

Legal entity responsible for the study

Menoufia University

Funding

None

Disclosure

All authors have declared no conflicts of interest.

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