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Poster lunch

1223 - Efficacy of T-DM1 in patients with HER2-positive metastatic breast cancer previously treated with pertuzumab (103P)

Date

18 Nov 2017

Session

Poster lunch

Presenters

Koshi Matsui

Citation

Annals of Oncology (2017) 28 (suppl_10): x26-x34. 10.1093/annonc/mdx654

Authors

K. Matsui1, A. Yoshikawa2, K. Oyama3, Z. Nozaki4, Y. Tanada4, M. Earashi5, K. Kiyohara6, T. Nagata7, W. Fukushima8, T. Shimizu9, K. Maeda10

Author affiliations

  • 1 Surgery, Toyama Prefectural Central Hospital, 930-8550 - Toyama/JP
  • 2 Department Of Surgery, Toyama City Hospital, 9398511 - Toyama/JP
  • 3 Department Of Surgery, Kouseiren Takaoka Hospital, 9338555 - Takaoka/JP
  • 4 Department Of Surgery, Toyama Red Cross Hospital, 9300859 - Toyama/JP
  • 5 Surgery, Yatsuo general hospital, 9392376 - Toyama/JP
  • 6 Department Of Surgery, Tonami General Hospital, 9391395 - Tonami/JP
  • 7 Department Of Surgery, Toyama University Hospital, 9300194 - Toyama/JP
  • 8 Derartment Of Surgery, Takaoka City Hospital, 933-8550 - Takaoka/JP
  • 9 Department Of Surgery, Saiseikai Toyama Hospital, 9318533 - Toyama/JP
  • 10 Depertment Of Surgery, Toyama Prefectural Central Hospital, 938550 - Toyama city/JP
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Resources

Abstract 1223

Background

The standard therapy for primary treatment of HER2-positive metastatic breast cancer (MBC) is combination therapy of pertuzumab (PER), trastuzumab (HER) and docetaxel (DTX). Although the effectiveness of trastuzumab emtansine (T-DM1) after HER treatment has been reported, there are few reports on the effectiveness of T-DM1 for patients treated with PER. We retrospectively investigated the effectiveness of T-DM1 on HER2-positive MBC previously treated with PER.

Methods

Between October 2013 and June 2017, 79 patients with HER2-positive MBC were treated with PER. 44 patients were investigated the subsequent treatment. 34 patients received T-DM1, and 10 patients received treatment other than T-DM1 after PER treatment.

Results

Median treatment line was 3.0 (1-9) vs 4.0 (1-9) in the T-DM1 treatment and other than T-DM1 treatment, respectively. The response rate was CR 0% vs 0%, PR 36.0% vs 25%, SD 32.0% vs 62.5%, PD 32.0% vs 12.5%, respectively. The objective response rate was 36.0% vs 20.0%. The clinical benefit rate was 48.0% vs 50.0%. Median time to treatment failure was 6.6 months vs 2.9 months, respectively. There was a significant difference in median overall survival; median not reached vs 19.6 months (p = 0.04).

Conclusions

OS was significantly better with administration of T-DM1 after PER treatment. Based on the results of this study, it was confirmed that efficacy of T-DM1 in patients with HER2-positive metastatic breast cancer previously treated with PER.

Clinical trial identification

Legal entity responsible for the study

Koshi Matsui

Funding

None

Disclosure

All authors have declared no conflicts of interest.

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