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Poster lunch

1315 - Clinical outcome of ifosfamide in combination with carboplatin in small cell lung cancer: Results from third- or further- line chemotherapy (500P)

Date

18 Nov 2017

Session

Poster lunch

Presenters

Myoungrin Park

Citation

Annals of Oncology (2017) 28 (suppl_10): x153-x154. 10.1093/annonc/mdx674

Authors

M. Park, J. Lee

Author affiliations

  • Department Of Internal Medicine, Division Of Pulmonology, Chungnam National University Hospital, 301-721 - Daejeon/KR
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Resources

Abstract 1315

Background

The number of available regimens which can be used in relapsed small-cell lung cancer (SCLC) is small and the data of the regimens is lack than those of non-small cell lung cancer. The goal of the present study is to evaluate the clinical outcome of ifosfamide and carboplatin (IC) regimen for third- or further-line chemotherapy in SCLC patients.

Methods

A retrospective analysis was conducted of all patients who received combination chemotherapy with IC regimenbetween 2011 and 2015 for SCLC. The data included baseline demographics, chemotherapy-related toxicities, therapeutic regimens that used and survival period.

Results

A total of 12 patients were administered IC regimen. All of the IC regimens were used in third- or further-line chemotherapy and 9 (75%) of cases were fourth-line therapy. Of the 37 chemotherapy-related toxicity events, 27 (73%) were hematologic toxicities and thrombocytopenia (n = 10 (27%)) was reported most frequently. The median overall survival (OS) after IC administration was 3.5 months. Patients with positive change of body mass index (BMI) before IC administration (p = 0.071), without multiple metastases at start of IC regimen (p = 0.001), refractory relapse after first line treatment (p = 0.082), partial response or stable disease to the IC treatment (p = 0.007) showed longer duration of OS.Table: 500P

Patient characteristics (n = 12) at diagnosis and point of IC administration

ParameterValue
Male10 (83.3%)
Pre-IC age: median (range)59 (43-67) years
Pre-IC ECOG
00 (0%)
14 (33.3%)
27 (58.3%)
31 (8.3%)
40 (0%)
SMK: median (range)40 (0-80) packyears
BMI: median (range)
at diagnosis23.31 (16.93-31.75) kg/m2
pre-IC23.07 (18.58-29.79) kg/m2
Pre-IC albumiin: median (range)3.75 (3.3-4.1) mg/dL
Pre-IC LDH: median (range)510.50 (367-1245) U/L
Pre-IC Sodium: median (range)135.70 (125.60- 138.50) mEq/L
Pre-IC Hb: median (range)11.30 (9.3-13.4) g/dL
TNM staging at diagnosis
IIIB2 (16.7%)
IV10 (83.3%)
VALG staging at diagnosis
LD2 (16.7%)
ED10 (83.3%)
Multiple metastases at start of IC regimen
No5 (41.7%)
Yes7 (58.3%)
Type of relapase after 1st line treatment
Sensitive6 (50%)
Refractory6 (50%)
Response to IC regimen
CR0 (0%)
PR2 (16.7%)
SD1 (8.3%)
PD9 (75%)
Initial treatment method
CCRTx2 (16.7%)
CTx10 (83.3%)
Line of therapy that IC regimen used
3rd2 (16.7%)
4th9 (75%)
5th1 (8.3%)

Conclusions

The IC regimen is a reasonable therapeutic arm for relapsed SCLC.

Clinical trial identification

Legal entity responsible for the study

Myoungrin Park

Funding

None

Disclosure

All authors have declared no conflicts of interest.

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