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Poster lunch

1729 - Characteristics and Outcome of Patient with Haematological Malignancy Admitted to the Intensive Care Unit : A Single-Centre Experience (526P)

Date

18 Nov 2017

Session

Poster lunch

Presenters

Agus Sunggoro

Citation

Annals of Oncology (2017) 28 (suppl_10): x155-x165. 10.1093/annonc/mdx676

Authors

A. Sunggoro, A. Arifin

Author affiliations

  • Internal Medicine, Faculty of Medicine, Sebelas Maret University, 57126 - Surakarta/ID
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Resources

Abstract 1729

Background

Hospitalized patients with haematological malignancy are at risk of developing critical illness. Critical illness in patients with haematological malignancy (HM) is often due to complications of treatment. Long-held assumptions of poor prognoses for patients with HM have meant that clinicians have been reluctant to admit them to the intensive care unit (ICU). However, over the past few years several centers across the world have shown that it is possible to achieve a meaningful survival in these patients.

Methods

The aim of this study was to assess the characteristics and outcomes of patient with haematological malignancy admitted to the intensive care unit (ICU). We performed a retrospective cohort study among adult HM patients admitted to the ICU in Moewardi Hospital between January 2015 and December 2016. Medical history, physical and laboratory findings on admission, and therapeutic interventions during ICU stay were recorded. The study endpoint was ICU mortality.

Results

Nineteen patients were admitted to ICU, the median age was 52 years (21-73), and 67% were female. The mean ICU length of stay was 3 days (SD 2.8). The main acute life-threatening diseases precipitating ICU transfer were septic shock (8 patients, 44%) and respiratory failure (5 patients, 28%). Acute Myeloid Leukemia (AML) was the main diagnosis in this study (39%). Most of these patients had anemia (72%) with the median of hemoglobin was 8.8 (3.9-12). Twenty eight percent of patients needed invasive mechanical ventilation and 60% of these died. ICU mortality was 50%.

Conclusions

Patients admitted to ICU with HM have high mortality. Early recognition of critical illness is required to enable prompt referral of patients who may benefit from critical care. Multicenter outcome studies on patients with HM who require ICU admission are needed.

Clinical trial identification

Legal entity responsible for the study

Faculty of Medicine, Sebelas Maret University

Funding

None

Disclosure

All authors have declared no conflicts of interest.

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