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Poster lunch

1020 - Breath alcohol concentrations in patients undergoing taxane chemotherapy: an observational pilot study (BrACT study) (507P)

Date

18 Nov 2017

Session

Poster lunch

Presenters

Alysson Wann

Citation

Annals of Oncology (2017) 28 (suppl_10): x155-x165. 10.1093/annonc/mdx676

Authors

A. Wann, S. Luen, D. Day, L. Spain, C. O'Callaghan, B. Yeo, S. White

Author affiliations

  • Medical Oncology, Olivia Newton John Cancer & Wellness Centre, 3084 - Heidelberg/AU
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Resources

Abstract 1020

Background

Taxane chemotherapy contains ethanol as a solvent and patients receiving this are at risk of elevated breath alcohol concentrations (BAC) and alcohol intoxication. This is the first Australian study using accredited testing methods provided by the Australian Federal Police (AFP) to determine if patients receiving taxanes have BAC exceeding the legal driving limit of 0.05%.

Methods

In this prospective observational pilot study, BAC were tested on two consecutive chemotherapy administration days as follows: prior to, immediately post, 30 minutes post and if still elevated, 60 minutes post infusion. The breathalyser was provided by the AFP. An elevated BAC (>0.05%) was confirmed with a venous blood alcohol concentration. Demographic data, infusion details (rate, volume, dosage) and symptoms of alcohol intoxication immediately after the infusion were collected.

Results

At a large Australian cancer centre between May to November 2016, 26 patients were recruited (81% female). Twenty patients had breast cancer, 5 prostate cancer and 1 lung cancer. Five had Asian ethnicity and 3 had underlying non-malignant liver disorders. Twenty received paclitaxel (11 as a single agent) and 6 docetaxel. BAC results are listed in table 1. Of the 5 patients (19%) with an elevated BAC on both occasions, 2 had paclitaxel, 2 had carboplatin + paclitaxel, 1 had trastuzumab + paclitaxel. All 5 had early breast cancer, were of non-Asian ethnicity, were more likely to experience symptoms of alcohol intoxication compared to those who only had elevated BAC recorded on one occasion, and 3 consumed alcohol monthly or less.Table: 507P

Timepoint 1Numbers with elevated BACMean BACRange BAC
Prior to chemotherapy0--
Immediately post chemotherapy9 (34%)0.012[0.01-0.014]
30 minutes post chemotherapy0--
Timepoint 2
Prior to chemotherapy0--
Immediately post chemotherapy8 (31%)0.014[0.01–0.019]
30 minutes post chemotherapy0--
Elevated BAC on both days5 (19%)0.012[0.01-0.014]

Conclusions

This prospective study in an Australian population showed that although 19% of taxane administrations led to a reproducible detectable BAC, none had levels above 0.05%. At 30 minutes post administration, all levels returned to normal. This pilot study is reassuring in that taxanes do not cause alcohol intoxication, although larger studies would be required to confirm this.

Clinical trial identification

Legal entity responsible for the study

Olivia Newton John Cancer & Wellness Centre

Funding

None

Disclosure

All authors have declared no conflicts of interest.

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