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Poster lunch

1918 - Association between HER2 Oncoprotein and Hormonal Receptors (Estrogen Receptor and Progesterone Receptor) on Breast Cancer (56P)

Date

18 Nov 2017

Session

Poster lunch

Presenters

Fikri Fulkiadli

Citation

Annals of Oncology (2017) 28 (suppl_10): x7-x15. 10.1093/annonc/mdx653

Authors

F. Fulkiadli1, D. Khambri2, W. Harahap3

Author affiliations

  • 1 Medical Student, Faculty of Medicine, Andalas University, 25127 - Padang/ID
  • 2 Surgery Department, RSUP Dr. M. Djamil, 25127 - Padang/ID
  • 3 Surgery Department, Faculty of Medicine, Andalas University, 25127 - Padang/ID
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Resources

Abstract 1918

Background

The expression of human epidermal growth factor receptors 2 (HER2) and hormonal receptors (estrogen receptor and progesterone receptors) on breast cancer are important markers that always be determined on breast cancer patients. Association between HER2 and hormonal receptors (ER and PR) expression are used as a prognostic and predictive factor on breast cancer. This research aimed to determine the association between HER2, ER, and PR on breast cancer.

Methods

This study was an analytical with cross-sectional design. This study was conducted from May 2015 – December 2015 in oncology division of surgery department RSUP DR. M. Djamil, Padang. Research subjects were 373 of breast cancer patients from 2011 – 2015. Chi square analysis test was used to determine the significant relationship between the variables.

Results

This study involved 124 cases with HER2+ and 249 cases with HER2-. Significant differences in the cases were ER+/HER2- (85.2%) compared with ER+/HER2 (14.8%) with p 

Conclusions

This study concluded that there were significant differences between expression of HER2 and hormonal receptors (ER and PR).

Clinical trial identification

This is not a trial idetification research

Legal entity responsible for the study

Medical Faculty of Andalas University

Funding

None

Disclosure

All authors have declared no conflicts of interest.

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