Abstract 1616
Background
Inflammation was identified to play a significant effect on progression and prognosis of esophageal cancer (EC). In current study, we investigated the prognostic value of fibrinogen (Fib), albumin (Alb), Alb-Fib ratio (AFR) and circulating blood ratios (NLR, dNLR, PLR and LMR) in patients with EC undergoing esophagectomy.
Methods
A total of 153 EC patients were included in present study, and all of them were clinical confirmed and underwent esophagectomy between January 2011 and December 2013. We detected the preoperative circulating Alb, Fib and counts of white blood cells (neutrophil, monocyte, lymphocyte and platelet), and obtained the survival data by 3 years’ following-up in the cases. X-tile software, Kaplan-Meier curve, Cox regression and predicted nomogram were used to evaluate the prognostic role of them in EC patients.
Results
The optimal cut-off points of Fib, Alb, AFR, NLR, dNLR, PLR and LMR were 3.2mg/dl, 38.2g/l, 9.3, 2.1, 4.3, 145.9 and 2.3, respectively. AFR(
Conclusions
Preoperative ADS score including AFR, Alb and dNLR was a prospective biomarker to predict clinical efficacy of adjuvent radio-chemotherapy and 3 year’ OS, and the nomogram including the score obviously improved the predicted survival efficacy for surgically resected EC patients.Preoperative ADS score including AFR, Alb and dNLR was a prospective biomarker to predict clinical efficacy of adjuvent radio-chemotherapy and 3 year’ OS, and the nomogram including the score obviously improved the predicted survival efficacy for surgically resected EC patients.
Clinical trial identification
Legal entity responsible for the study
Medical Ethics Committee of the Second Affiliated Hospital of Nanchang University (Jiangxi, China).
Funding
None
Disclosure
All authors have declared no conflicts of interest.