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Poster lunch

1616 - A novel ADS prognostic score containing prospective AFR, Alb and dNLR predicted overall survival in esophageal cancer patients (38P)

Date

18 Nov 2017

Session

Poster lunch

Presenters

Qiu-fang Gao

Citation

Annals of Oncology (2017) 28 (suppl_10): x7-x15. 10.1093/annonc/mdx653

Authors

Q. Gao, X. Huang, J. Qiu, H. Ying, X. Wang

Author affiliations

  • Jiangxi Province Key Laboratory Of Laboratory Medicine, 2nd Affiliated Hospital of Nanchang University, 330006 - Nanchang/CN
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Resources

Abstract 1616

Background

Inflammation was identified to play a significant effect on progression and prognosis of esophageal cancer (EC). In current study, we investigated the prognostic value of fibrinogen (Fib), albumin (Alb), Alb-Fib ratio (AFR) and circulating blood ratios (NLR, dNLR, PLR and LMR) in patients with EC undergoing esophagectomy.

Methods

A total of 153 EC patients were included in present study, and all of them were clinical confirmed and underwent esophagectomy between January 2011 and December 2013. We detected the preoperative circulating Alb, Fib and counts of white blood cells (neutrophil, monocyte, lymphocyte and platelet), and obtained the survival data by 3 years’ following-up in the cases. X-tile software, Kaplan-Meier curve, Cox regression and predicted nomogram were used to evaluate the prognostic role of them in EC patients.

Results

The optimal cut-off points of Fib, Alb, AFR, NLR, dNLR, PLR and LMR were 3.2mg/dl, 38.2g/l, 9.3, 2.1, 4.3, 145.9 and 2.3, respectively. AFR(

Conclusions

Preoperative ADS score including AFR, Alb and dNLR was a prospective biomarker to predict clinical efficacy of adjuvent radio-chemotherapy and 3 year’ OS, and the nomogram including the score obviously improved the predicted survival efficacy for surgically resected EC patients.Preoperative ADS score including AFR, Alb and dNLR was a prospective biomarker to predict clinical efficacy of adjuvent radio-chemotherapy and 3 year’ OS, and the nomogram including the score obviously improved the predicted survival efficacy for surgically resected EC patients.

Clinical trial identification

Legal entity responsible for the study

Medical Ethics Committee of the Second Affiliated Hospital of Nanchang University (Jiangxi, China).

Funding

None

Disclosure

All authors have declared no conflicts of interest.

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