Abstract 1146
Background
Breast cancer (BC) is the most common malignancy among women in different societies. Several studies on interactive effect of marine algae extracts and its active ingredient in fucoidan has been shown to control cell division in BC cells in vitro. In this article, we aimed to review the role seaweed extract and fucoidan on BC cells proliferation.
Methods
In this review, original and reviews studies published from 2006 to 2013 were summarized through PubMed, Google Scholar, Science Direct an Medline by searching for marine algae, Fucoidan and apoptosis as key words.
Results
Fucoidan, a sulfated polysaccharide compounds derived from brown algae and marineInvertebrates, are actively studied for some curative and preventive biological activities, such as anti-tumor activity in cancer. These agents have shown anticancer properties in breast, lung, and blood cancer cells. Seaweed extract and Fucoidan inhibited the proliferation of human cancer cells in normal human epidermal cells. It is effective in regulating the expression of C-MYC, cyclin D1, SURVIVIN genes and consequently the expression of these gene where down regulated. It seems that an intraperitoneal injection of Fucoidan, in animal models of BCreduce volume and weight of tumor. Studies show that after treatment by Fucoidan, cytochrom C releases from the mitochondria to the cytosol, and activates caspase 3 protein.Fucoidan might also induced apoptosis by reducing the cellular capacity through the reduction of cell glutathione capacity. Studies have showed that Fucoidan, inhibited cancer cells growth in G1phase of cell cycle, as well.
Conclusions
According to studies, marine algae extract and Fucoidan provide inhibitory effects on the growth and proliferation of breast cancer cells. Fucoidan could attribute in a prevention and also might considered as effective factor in chemothrepy.
Clinical trial indentification
Legal entity responsible for the study
Tabriz University of Medical Sciences
Funding
Tabriz University of Medical Sciences
Disclosure
All authors have declared no conflicts of interest.