Blood transfusion reaction were found in 0.3% hospitalized cancer patients. Careful evaluation is needed to report the reaction of transfusion. The purpose of the study is to know the incidence and risk factor of transfusion reactions in Indonesian cancer patients.
Age, gender, type of cancer, and karnofsky performance scale were evaluated in this study. Hospitalized cancer patients who underwent blood transfusion with any indication were evaluated for the type of blood transfusion, adverse effects, premedication given, and past transfusion history. Univariate analysis was performed using Chi Square Test. This study was done during January – July 2015 in our general hospital in Karawaci region.
Fifty six patients were collected during this study period. Most patients were female (58.9%) and the median age of the patients was 49 (2–78). The types of cancer were solid tumor (73.2%) and hematologic malignancy (26.8%). Packed Red Blood Cells were administered in 55 patients (96.5%), Platelet Concentrate in 2 patients (3.5%), and Washed Red Blood Cells in 1 patient (1.8%). Transfusion reaction occurred in 12 patients (21.4%). The most common reaction were fever in 7 cases (58.3%), dyspnea in 4 cases (33.3%), itching in 2 cases (16.67%), light-headed in 2 cases (16.67%), chills in 2 cases (16.67%), petechiae in 1 cases (0.83%), loss of consciousness in 1 cases (0.83%), and palpitation in 1 cases (0.83%). Twenty five percents were having history of transfusion reaction. Diphenhydramine (33.3%) and diuretic drugs (8.3%) were used as premedication in cases. Karnofsky performance scale was significantly correlated with blood transfusion reaction (p < 0.05). There was no significant correlation between antihistamine usage and blood transfusion reaction (p > 0.05).
Incidence of transfusion reaction in cancer patient was 21.4%. There was significant correlation between Karnofsky performance scale and blood transfusion reaction. Use of antihistamine was not correlated with blood transfusion reaction.
Clinical trial identification
All authors have declared no conflicts of interest.