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Tuberculosis exposure and the risk of cancer

Date

19 Dec 2015

Session

Poster presentation 1

Presenters

Vincent Yi-Fong Su

Citation

Annals of Oncology (2015) 26 (suppl_9): 85-92. 10.1093/annonc/mdv526

Authors

V.Y. Su

Author affiliations

  • Department Of Chest Medicine, Taipei Veterans General Hospital, 112 - Taipei/TW
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Resources

Abstract 1196

Aim/Background

The association of latent tuberculosis infection (LTBI) with subsequent cancer remains unclear. We investigated the risk of future cancer among tuberculosis (TB) contacts with or without subsequent TB activation.

Methods

Using the Taiwan National Health Insurance Research Database, we conducted a nationwide population-based study. TB Contacts during 1997–2012 were included as the study cohort. Patients with antecedent cancer and TB were excluded. Data from 11,522 TB contacts and 46,088 age-, sex-, and enrollment date–matched subjects during 1997–2012 were analyzed. The two cohorts were monitored until December 31, 2012 for incidence of cancer and TB infection. LTBI was defined as a TB contact with subsequent TB activation. The primary endpoint was occurrence of newly diagnosed cancer.

Results

There was no difference in cancer development between the TB contact cohort and comparison cohort (log-rank test, p = 0.714). After multivariate adjustment, the hazard ratio (HR) for cancer among the LTBI patients was 2.29 [95% confidence interval (CI), 1.26–4.17; p = 0.007]. There was increase in cancer incidences for several specific cancer types, including multiple myeloma (HR 340.28), lung (HR 2.69), kidney and bladder (HR 6.16), hepatobiliary (HR 2.36), and gastrointestinal (HR 2.99) cancers. None of the 136 TB contacts who received isoniazid prophylaxis developed cancer.

Conclusions

TB exposure did not increase the risk of future cancer. LTBI patients had a higher risk of future cancer. However, isoniazid prophylaxis may reduce this risk.

Clinical trial identification

This study is not a clinical trial.

Disclosure

All authors have declared no conflicts of interest.

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