To evaluate the efficacy of Hyperbaric Oxygen (HBO) Therapy for prostate cancer patients who developed radiation induced side-effects.
Between April 2006 and March 2015, 14 prostate cancer patients treated with External beam radiation therapy (dosage 69.3 - 72 Gy) developed RTOG/EORTC grade 3 radiation induced side-effects at Nippon Medical School. Patients received 100% oxygen in a hyperbaric chamber at a pressure of 2.5 atmospheres absolute, 20 minutes pressurization, 60 minutes treatment, 20 minutes decompression once a day, 6 times a week. 20 HBO treatments were performed per course. After every course of HBO treatment, therapeutic effect was evaluated using RTOG/EORTC Late Radiation Morbidity Scoring Schema.
The average age was 74.3 years old. 8 hemorrhagic proctitis, and 6 hemorrhagic cystitis were treated with a mean of 20 (range 10-97) HBO treatments. The mean duration for the side effect to occur was 13 months (range 6-24 months), the mean duration between the onset of side effect and beginning of HBO therapy was 10 months (range 5-18months). 6 patients completely recovered, 5 patients had improvement of side-effects, 1 patient had no improvement and was treated with argon plasma coagulation, and 1 patient could not continue the therapy.
HBO therapy can be a primary option for the management of radiation induced side-effects.
Clinical trial identification
All authors have declared no conflicts of interest.