Venous thromboembolic disease is a common complication in cancer patients with a negative impact on their survival. In lung cancer, the scientific evidence for thrombosis during treatment with chemotherapy is limited. The objective of this study was to describe the incidence of thromboembolic events (TE) in patients with metastatic NSCLC, occurring during treatment with platinum-based chemotherapy, in the TorrecÃ¡rdenas Hospital.
It's about a retrospective study of 100 patients with stage IV NSCLC (EGFR / ALK native) receiving first-line platinum-based chemotherapy. TE happening since the beginning of chemotherapy to 1.5 months after the last administration, are described.
Median age was 59 years (37-78). 80% male. Most frequent histology: adenocarcinoma (70%) and degree of differentiation G3 (57%). Visceral metastatic disease (60%). 70 patients were treated with cisplatin-based and 30 patients received carboplatin regimen. 13 patients (13%) experienced a TE during treatment (8 episodes of pulmonary thromboembolism and 5 episodes of deep vein thrombosis). 13% (9/70) of TE in patients exposed to cisplatin vs 10% (4/30) in patients exposed to carboplatin. Most events occurred in the first 3 cycles (60%). The median PFS was similar in patients with and without TE (7.5 vs. 8.1 months). The median OS was lower in patients with TE (7.1 versus 11.7 months).
In our study, the incidence of TE in patients with metastatic NSCLC is higher than that described in previous studies. TE most occur in the first three cycles, and their appearance is associated with increased mortality. Adenocarcinoma, degree of differentiation 3, visceral metastases and chemotherapy based on platinum, are risk factors for TE in stage IV NSCLC.
Clinical trial identification
All authors have declared no conflicts of interest.