The prognostic value of immunohistochemical studies in diagnosis and treatment of ovarian germ cell tumors of childhood and adolescence

Date

20 Dec 2015

Session

Poster presentation 2

Presenters

Anvar Shukullaev

Citation

Annals of Oncology (2015) 26 (suppl_9): 80-84. 10.1093/annonc/mdv525

Authors

A.T. Shukullaev1, N.S. Yuldasheva2

Author affiliations

  • 1 Pediatric Oncology, National Cancer Research Center of Uzbekistan, 100174 - Tashkent/UZ
  • 2 Gynecology, National Cancer Research Center of Uzbekistan, 100174 - Tashkent/UZ
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Aim/Background

To study the effectiveness of immunohistochemical studies in diagnosis and tactics treatment of germ cell ovarian tumors of childhood and adolescence.

Methods

We observed 30 patients with malignant ovarian germ cell tumors of the I - IV stages. The diagnosis put by using standard, accepted methods of determination of tumor markers AFP, CA-125 and НCG. Of the 30 patients, 12 (52%) were aged 1 to 14, 18 (48%) of 15 to 18 years. All patients after operation was carried out immunohistochemical study with bcl-2 oncoprotein and p53 suppressor gene.

Results

Of the 30 (100%) in 6 patients (20%) was high expression of the oncoprotein bcl-2, 9 (30%) - moderately severe, 15 (50%)–was low expression. The study of tumor suppressor gene p53 revealed that in 8 (26.6%) patients had high expression, in 12 (40%) - moderately severe in 10 (33.3%) - was low expression. Conducted immunohistochemical studies have shown that in the group with high positive expression of bcl-2 and p53 had a more aggressive course of tumor process, followed in these patients revealed early recurrences and metastases, which required a more aggressive course of chemotherapy (6 to 8 courses by scheme BEP, PVB or VEP), and in the group with low or negative expression of p53 and bcl - 2 effective schemes and more sparing regimens (4 to 6 courses of BEP scheme, EP). (Bleomycini, etoposydi, cysplatini).

Conclusions

The performed immunohistochemical studies have shown that the definition of indicators oncoprotein bcl - 2 and the gene - the p53 tumor suppressor is not only diagnostic value but also has important prognostic and selection of treatment of ovarian germ cell tumors of childhood and adolescence.

Clinical trial identification

Disclosure

All authors have declared no conflicts of interest.

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