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The effectiveness of neoadjuvant inraarterial poly chemotherapy in cervix cancer

Date

20 Dec 2015

Session

Poster presentation 2

Presenters

Odiljon Akhmedov

Citation

Annals of Oncology (2015) 26 (suppl_9): 80-84. 10.1093/annonc/mdv525

Authors

N.S. Yuldasheva, O.M. Akhmedov

Author affiliations

  • Gynecology, National Cancer Research Center of Uzbekistan, 100174 - Tashkent/UZ
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Resources

Abstract 1205

Aim/Background

Cervix cancer is the most frequent cancer disease in woman. In present time standard primary treatment for locally advanced cervix cancer is radiation (RT) with concomitant platinum-based chemotherapy (CT). Incomplete local control and the appearance of distant disease herald poor survival and warrant evaluation of new primary strategies.

Methods

The role of neoadjuvant chemotherapy (NAC) in locally advanced cervical cancer has been of interest for the last 25 years, and in many countries, NAC has become the standard of care. Experience with high-dose-density NAC in cervical cancer management in 141 women . High-dose-density neoadjuvant chemotherapy and radical surgery has resulted in high clinical response rates and seems to be feasible in the management of stage IB bulky cervical cancer. Neoadjuvant chemotherapy reduces tumor volume and positivity of lymph nodes and thus minimizes the need for postoperative radiotherapy or chemoradiotherapy. Tumor size reduction and node negativity allows less radical surgical procedures such as modified radical hysterectomy or nerve-sparing radical hysterectomy. Early and especially late toxicity of our high-dose density chemotherapy is acceptable. Neoadjuvant chemotherapy followed by surgery represents a valid alternative to primary chemoradiotherapy in young and sexually active patients.

Results

Five-year survival in patients who underwent surgery in our study was 80.6%. Currently, 3 papers with 3 approaches have been published on NAC before fertility-sparing surgery. One of the limitations of fertility-preserving surgery is deep stromal invasion and tumors larger than 2 cm. The idea underlying NAC is to reduce the size of the cervical tumor to preserve fertility. In the present paper, we also review our experience with high-dose-density NAC in fertility-sparing surgery in 15 women

Conclusions

The method of cervical cancer therapy using intra-arterial regional long duration infusion was developed. Infusions were performed through the catheter, placed into internal iliac artery, by the following regimen. Total duration of infusion was 72 hours. Offered method in a short period allows achieving tumor regression and improving life quality. Moreover, the method shows good long-term result.

Clinical trial identification

Disclosure

All authors have declared no conflicts of interest.

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