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Poster presentation 1

1146 - Prognostic value of disseminated tumor cells (DTC) identification in bone marrow from patients with advanced gastric or esophagogastric junction (EGJ) adenocarcinoma (interim results)

Date

19 Dec 2015

Session

Poster presentation 1

Presenters

Ekaterina Obarevich

Citation

Annals of Oncology (2015) 26 (suppl_9): 8-15. 10.1093/annonc/mdv518

Authors

E.S. Obarevich1, N.S. Besova2, N.N. Tupitsyn3, M.M. Davydov4, V.A. Gorbunova2, T.A. Titova2

Author affiliations

  • 1 Chemotherapy, N. N. Blokhin Russian Cancer Research Center, 115478 - Moscow/RU
  • 2 Chemotherapy, N. N. Blokhin Russian Cancer Research Center, Moscow/RU
  • 3 Haematopoiesis Immunology Lab., N. N. Blokhin Russian Cancer Research Center, Moscow/RU
  • 4 Thoraco-abdominal, N. N. Blokhin Russian Cancer Research Center, Moscow/RU
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Abstract 1146

Aim/Background

To identify DTC in bone marrow (BM) as a therapeutically significant target to predict survival of patients with stage IV gastric cancer.

Methods

A total of 27 patients with advanced gastric cancer were enrolled, median age 52 years. All patients received thriplet chemotherapy. Baseline BM-DCT were identified by flow cytometry. BM-DTC positivity was defined as at least 1 tumor cell per 10 million myelokaryocytes.

Results

BM-DTC were found in 18 of 27 patients. Median survival was 6.5 months in BM-DTC positive vs. 9.2 months in BM-DTC negative patients (p = 0.019). The table below summarizes the clinicomorphological findings. Table. Relationship between DTC-positivity and clinicomorphological parameters.

Parameter BM-DTC positive patients n, % BM-DTC negative patients n, % p-Value
Tumor site
Esophagogastric junction 9/18 (50) 1/9 (11.1) 0.049
Body of stomach 6/18 (33.3) 4/9 (44.4) 0.573
Anthrum 3/18 (16.7) 2/9 (22.2) 0.726
Total stomach 0/18 (0) 2/9 (22.2) 0.038
Adenocarcinoma histology
Moderately differentiated 4/18 (22.2) 2/9 (22.2) 1
Poorly differentiated 10/18 (55.6) 1/9 (11.1) 0.027
Signet-ring cell 4/18 (22.2) 6/9 (66.7) 0.024
Metastasis sites
Liver 6/18 (33.3) 3/9 (33.3) 1
Peripheral lymph nodes 4/18 (22.2) 3/9 (33.3) 0.535
Retroperitoneal lymph nodes 8/18 (44.4) 2/9 (22.2) 0.260
Ovaries 1/18 (5.6) 1/9 (11.1) 0.603
Peritoneal carcinomatosis 9/18 (50) 8/9 (88.9) 0.049

Conclusions

The presence of DTC in BM of patients with advanced gastric cancer is a poor prognostic factor associated with a high risk of early progression. BM-DTC were identified significantly more frequently in cases with EGJ and total gastric cancer, and in patients free from peritoneal carcinomatosis; there was also a correlation with tumor histology. The study is in ongoing

Clinical trial identification

Disclosure

All authors have declared no conflicts of interest.

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