Oops, you're using an old version of your browser so some of the features on this page may not be displaying properly.

MINIMAL Requirements: Google Chrome 24+Mozilla Firefox 20+Internet Explorer 11Opera 15–18Apple Safari 7SeaMonkey 2.15-2.23

Poster presentation 2

815 - Prognostic factors among ER+ HER2- breast cancer patients in Malaysia


20 Dec 2015


Poster presentation 2


Yvonne Lee


Annals of Oncology (2015) 26 (suppl_9): 16-33. 10.1093/annonc/mdv519


Y.Y. Lee1, N.A.M. Taib2, S.S. Yeoh1, C.H. Yip2, N. Bhoo-Pathy3

Author affiliations

  • 1 Outcome And Evidence, Pfizer Malaysia Sdn Bhd, 59200 - Kuala Lumpur/MY
  • 2 Surgery, University of Malaya Faculty of Medicine, Kuala Lumpur/MY
  • 3 Social And Preventive Medicine, University of Malaya Faculty of Medicine, Kuala Lumpur/MY


Abstract 815


Breast cancer is a multifaceted disease with diverse clinical, pathologic and molecular features which led to different prognostic outcomes. We aim to examine factors that influence survival outcome among ER+ HER2- patients from a single institution.


Data of patients diagnosed between January 1, 2005 and December 1, 2011 was extracted from the University Malaya Medical Centre Breast Cancer Registry. Kaplan-Meier method was used to estimate overall survival. Overall survival was defined from date of diagnosis to date of death from any cause. Log rank tests and Cox hazards regression model were used to compare survival and identify prognostics factors. Stage 4 patients were excluded from univariate and multivariate analysis.


In 951 patients with ER + /HER2- breast cancer, median age at diagnosis was 54 years (range, 24-89) with 50.7% Chinese followed by Malays (35.1%) and Indians (13.3%). 94.5% of breast cancer patients received hormone therapy while 91% had surgery. Slightly over half of the cohort (53.2%) present with T2 tumor size (2-5cm). 5 years survival probability according to stage; stage 1, 95.4% (95% CI, 91.7-97.4), stage 2, 88.6% (95% CI, 84.7-91.6), stage 3, 74.9% (95% CI, 68.3-80.4) and stage 4, 27.5% (95% CI, 16.1-40.1). 7.4% were diagnosed with stage 4 with median survival of 2.4 years (95% CI, 1.9-3.1). In univariate analysis; increasing age (p < 0.001), tumor size (p < 0.001) and number of lymph nodes (p < 0.001), significantly led to poorer survival while those receiving hormone therapy (HR: 0.50, 95% CI: 0.27-0.93) and surgery (HR: 0.11, 95% CI: 0.05-0.23) had greater survival benefits. Ethnicity and grade was not associated with survival outcome. Age, tumor size and number of lymph nodes remain significant as independent survival predictor in the multivariate model.


In this cohort, we found increasing age, tumor size and number of lymph node was associated with poorer survival outcome among ER + /HER2- breast cancer patients. Ethnic disparities in survival outcome were not apparent in this molecular subset.

Clinical trial identification



Y.Y. Lee: employee of Pfizer Malaysia Sdn Bhd. All other authors have declared no conflicts of interest.

This site uses cookies. Some of these cookies are essential, while others help us improve your experience by providing insights into how the site is being used.

For more detailed information on the cookies we use, please check our Privacy Policy.

Customise settings