Prediction of response and outcome with EUTOS score in Indian AYA CML CP patients on frontline imatinib: A university hospital retrospective analysis

Date

19 Dec 2015

Session

Poster presentation 1

Presenters

Ranga Raman Ganta

Citation

Annals of Oncology (2015) 26 (suppl_9): 85-92. 10.1093/annonc/mdv526

Authors

R.R. Ganta¹, S. Nasaka¹, S. Gundeti², L.S. Maddali²

Author affiliations

¹ Medical Oncology, Nizam's Institute of Medical Sciences, 500082 - Hyderabad/IN
² Dept. Of Medical Oncology, Nizam's Institute of Medical Sciences, 500082 - Hyderabad/IN

Resources

Abstract 1148

Aim/Background

The Sokal (1984) and Hasford/Euro (1998) scores were developed in the chemotherapy and interferon eras respectively and are still widely used as prognostic indicators in CML patients. Recently (2011), European Treatment and Outcome Study (EUTOS) scoring metric was introduced to risk stratify CML patients on Imatinib treatment. CML is predominantly a disease of elderly, but around 5-10% of patients are adolescent and young adults (AYA). Data on presentation, risk stratification and outcome in this population was lacking. It lead us to study the effectiveness of EUTOS risk score in predicting the response and outcome among AYA CML-CP patients on front line Imatinib.

Methods

Hospital records of AYA CML CP patients (age 15-30 years) from 2010 to 2012, were analyzed retrospectively for clinical features, EUTOS risk score, cytogenetic, molecular response and EFS at the end of three years. All patients received Imatinib under the Glivec international patient assistance program (GIPAP).

Results

A total of 39 patients were included in this study, with the median age of 24 years (range 15-30years) and male preponderance (M:F- 1.2:1). Majority (72%) of them were in EUTOS low risk group. Complete cytogenetic response [CCyR] rate at 12 months was 76% and 73% in low and high risk groups respectively. Major molecular response [MMR] rate at 18 months was 85% and 79% in low and high risk groups respectively. 3 year EFS was 89% and 80% in low and high risk groups respectively.

Risk groups response and outcome comparison

Response â	EUTOS low risk n = 28 (72%)	EUTOS high risk n = 11 (28%)	p value (fishers test)	PPV for low risk	NPV for high risk
CHR at 3mon	28 (100%)	9 (81%)	0.07	75%	100%
CCyR at 12mon	22 (78%)	5 (45%)	0.06	81%	50%
MMR at 18mon	24 (86%)	6 (54%)	0.08	80%	55%
EFS at 36mon	26 (92%)	6 (54%)	0.01	81%	71%

Conclusions

EUTOS low risk AYA CML CP patients on Imatinib responded better than high risk, but not statistically significant. Low risk patients had statistically significant higher 3 year EFS than high risk. It effectively predicted the outcome but not the response in AYA CML CP.

Clinical trial identification

N/A

Disclosure

All authors have declared no conflicts of interest.

Resources from the same session

19 Dec 2015