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Effects of smoking habit in NSCLC with KRAS mutation in pathological stage I

Date

20 Dec 2015

Session

Poster presentation 2

Presenters

Hiroaki Kuroda

Citation

Annals of Oncology (2015) 26 (suppl_9): 125-147. 10.1093/annonc/mdv532

Authors

H. Kuroda1, K. Seto2, T. Yoshida3, T. Mizuno3, N. Sakakura3, T. Hida3, Y. Yatabe4, Y. Sakao5

Author affiliations

  • 1 Thoracic Surgery, Aichi Cancer Center Hospital, 464-8681 - Nagoya/JP
  • 2 Thoracic Surgery, Aichi Cancer Center Hospital, Nagoya/JP
  • 3 Department Of Thoracic Oncology, Aichi Cancer Center Hospital, 464–8681 - Nagoya/JP
  • 4 Department Of Pathology And Molecular Diagnosis, Aichi Cancer Center Hospital, 464-8681 - Nagoya/JP
  • 5 Department Of Thracic Surgery, Aichi Cancer Center Hospital, Nagoya/JP
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Resources

Abstract 1351

Aim/Background

KRAS mutation plays important roles in the pathobiology of NSCLC and is well known to the resistance of EGFR inhibitors. KRAS mutation is strongly associated with smoking habit, but the non to light smoker having KRAS mutation rarely exist.

Methods

We conducted a retrospective study of 104 patients diagnosed as KRAS mutation compared to 217 patients with the diagnosis as Wild type in pathological stage I. The proportion of non to light smoker {smoking index (SI): 0 to 400} were 37.5 (39/104) in the patients with KRAS mutation.

Results

KRAS with more than 400 in SI showed a shorter survival than KRAS with non to light smoker or Wild type (p = 0.03 and p < 0.01). The maximum tumor size and mediastinal size on preoperative CT was equivalent between the difference of smoking habit in KRAS mutation. Preoperative CEA was 4.56-fold higher in KRAS with more than 400 in SI than those with non to light (p < 0.01).

Conclusions

Our results suggested that KRAS mutation showed the poor prognosis in spite of stage I NSCLC. However, non to light smoker might have the possibility of contribution to improve prognosis among them.

Clinical trial identification

Disclosure

All authors have declared no conflicts of interest.

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