Oops, you're using an old version of your browser so some of the features on this page may not be displaying properly.

MINIMAL Requirements: Google Chrome 24+Mozilla Firefox 20+Internet Explorer 11Opera 15–18Apple Safari 7SeaMonkey 2.15-2.23

Poster presentation 1

721 - Early tumor shrinkage (ETS) and depth of response (DpR) in patients with advanced gastric cancer (AGC) receiving S1 plus cisplatin (SP) or capecitabine plus cisplatin (XP)


19 Dec 2015


Poster presentation 1




Annals of Oncology (2015) 26 (suppl_9): 42-70. 10.1093/annonc/mdv523


N. Sugimoto1, T. Yoshinami1, S. Yamamoto1, T. Yagi2, F. Imamura1

Author affiliations

  • 1 Clinical Oncology, Osaka Medical Center for Cancer and Cardiovascular Dideases, 537-8511 - Osaka/JP
  • 2 Clinical Oncology, Osaka Medical Center for Cancer and Cardiovascular Dideases, Osaka/JP


Abstract 721


In the Japanese Gastric Cancer Treatment Guideline (4th edition), S1 plus cisplatin (SP) is mentioned the standard (recommendation 1) and capecitabine plus cisplatin (XP) is considered as recommendation 2 for AGC in first-line setting. But few reports were existed about the comparison between XP and SP. Moreover, no report was found about the comparison of Early tumor shrinkage (ETS) and depth of response (DpR) between them.


The selection criteria were pathologically proven AGC (HER2 negative or unknown); no previous chemotherapy; performance status 0-2; able to oral intake; and adequate organ functions. The patients in XP group, capecitabine 1,000mg/m2 was given orally twice daily for 14days followed by a 7-day rest; cisplatin 80mg/m2 on day1 was given by intravenous infusion. In SP group, S1 40mg/m2 was given orally twice daily for 21 days followed by a 14-day rest and cisplatin 60mg/m2 intravenous infusion on day8.


The analysis covered 115 patients over the period from May 2008 to June

2014. The median age was 64 years (range 22-81); 76 males and 39 females; PS 0/1/2 score 85/29/1; 31 patients were treated XP and 84 patients were treated SP. Progression-free survival and overall survival were 6.6 and 16.4 months with XP and 6.1 and 13.3 months with SP (no significant difference). The response rates were XP/SP 61%/50%. The ETS (over 20% tumor shrinkage in 6-8weeks) rate were 83% in XP and 61% in SP (p = 0.09). DpR were 47.1% in XP and 40.5% in SP (p = 0.31). The rate of grade 3-4 toxicity in XP/SP were; neutropenia 23%/15%, anemia 16%/20%, nausea 0%/3%, anorexia 3%/ 8%, fatigue 0%/ 4%, hyponatremia 3%/0%. There was no treatment death in both groups.


It is suggested that XP can give AGC patients high ETS rate and DpR with safety. So we are recruiting the prospective study for AGC patients with multiple lymph node metastases in neoadjuvant setting (OGSG 1401, UMIN 000014071).

Clinical trial identification


N. Sugimoto: Chugai, Taiho, Yakult, Eli Lilly, Merckserono, Takeda. All other authors have declared no conflicts of interest.

This site uses cookies. Some of these cookies are essential, while others help us improve your experience by providing insights into how the site is being used.

For more detailed information on the cookies we use, please check our Privacy Policy.

Customise settings