Direct results of combined treatment of hepatoblastoma in children

Date

19 Dec 2015

Session

Poster presentation 1

Presenters

Farxod Hayitov

Citation

Annals of Oncology (2015) 26 (suppl_9): 42-70. 10.1093/annonc/mdv523

Authors

F.E. Hayitov, T.Q. Mustafaev, A.T. Shukullaev, K.Z. Iskandarov

Author affiliations

  • Pediatric Oncology, National Cancer Research Center of Uzbekistan, 100174 - Tashkent/UZ
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Resources

Aim/Background

To learn advantages of complex treatment.

Methods

From 2010 to 2014 in the department of children's oncology, the National Cancer Center of Uzbekistan treated 14 patients with hepatoblastoma. The age of patients was 16 months on average. Of these 8 (57.0%) male and 6 (43.0%) female. On admission, all patients performed the standard methods of investigation (examination, chest X-ray, ultrasound, CT, AFP levels, a set of blood tests and a biopsy of the tumor incisional biopsy of the tumor). In 8 (57.0%) patients with tumor are placed in the right lobe of the liver, in 3 (21.5%) - in the left lobe and 3 (21.5%) patients had total liver involvement. In the first phase all patients received neoadjuvant chemotherapy (from 4 to 6 courses) scheme DDP / DOXO / CARBO (doxorubicin and cisplatin + carboplatin). The effectiveness of ongoing neoadjuvant chemotherapy was assessed by ultrasound, CT and the level of AFP in the blood. Chemotherapy held against the background of a cover therapy.

Results

After neoadjuvant chemotherapy in 7 (50.0%) patients had a reduction of tumor volume more than 75% in 3 (21.5%) - more than 50%, and 3 (21.5%) - stabilization process and 1 (7.1%) patients - the progression of cancer. Depending on the effectiveness of chemotherapy and tumor localization in 10 (71.4%) patients performed surgical treatment. Of these, 4 (28.6%) patients underwent resection VII-VIII segments 3 (21.5%) - resection II - III of segments in 1 (7.1%) - resection segment VII and 2 (14 3%) left-hand hemihepatectomy. It should be noted that neoadjuvant chemotherapy allows you to perform radical surgery.

Conclusions

A combined approach using a modern scheme of chemotherapy programs at hepatoblastoma in children creates the possibility of radical surgery and significantly improves the results of treatment.

Clinical trial identification

Disclosure

All authors have declared no conflicts of interest.

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