Oops, you're using an old version of your browser so some of the features on this page may not be displaying properly.

MINIMAL Requirements: Google Chrome 24+Mozilla Firefox 20+Internet Explorer 11Opera 15–18Apple Safari 7SeaMonkey 2.15-2.23

Concurrent 3-DCRT plus S-1 in treatment of elderly patients with esophageal cancer in Chinese population: a meta-analysis of 13 trials

Date

20 Dec 2015

Session

Poster presentation 2

Presenters

Qiu Enyi

Citation

Annals of Oncology (2015) 26 (suppl_9): 125-147. 10.1093/annonc/mdv532

Authors

Q. Enyi1, Z. Xiyue2, S. Jie1, Z. Jin1

Author affiliations

  • 1 Department Of Radiation Oncology, Wenzhou Central Hospital, 325000 - Wenzhou/CN
  • 2 Department Of Anesthesiology, 1st Affiliated Hospital of Wenzhou Medical College, 325000 - Wenzhou/CN
More

Resources

Abstract 354

Aim/Background

To evaluate the efficacy and safety of concurrent three-dimensional conformal radiotherapy(3-DRT) plus S-1 vs 3-DRT in patients with esophageal cancer in Chinese population.

Methods

We searched the relevant decade data(2005.1–2015.4),from domestic and foreign relevant databases(PubMed, Medline, Cochrane Library, Wanfang Data, Chinese Journal Database),meeting the conditions of the clinical randomized controlled trials,and evaluated the quality of each document according to the Cochrane Review's handbook 5.0.We used Meta-analysis method to analysis the published literatures about clinical randomized controlled trials, which were concurrent three-dimensional conformal radiotherapy plus S-1 in treatment of elderly patients with esophageal cancer RevMan5.1 statistical analysis software analysised corresponding research index.

Results

13 separate clinical randomized controlled trials including 894 cases were researched into the Meta-analysis.Objective responsiveness and survival:The overall response(CR + PR) rates, 1-year overall survival rates and 2-year overall survival rates(P < 0.05)of CCRT group were superior to RT group The RR Values and 95%CI( confidence interval) were 1.37(1.26 ∼ 1.48 ), 1.35(1.19 ∼ 1.53), 1.58(1.26 ∼ 1.99 ) But the 3-year overall survival rates were no statistically significant differences(P >0.05) Adverse reactions:The grade 3 ∼ 4 gastrointestinal adverse reactions , the grade 3 ∼ 4 gastrointestinal radiation esophagitis and the grade 3 ∼ 4 neutropenia were more severe in the cCRT group than in the RT group(P < 0.05),the RR and 95%CI were 62.31(1.20 ∼ 4.43), 1.74(1.14 ∼ 2.67), 6.33(2.37 ∼ 16.92) But There were no grade 3 ∼ 4 radiation bronchitis or pneumonitis in both groups.The funnel plot showed no significant publication bias in each indexes .

Conclusions

The short- term response rates and survival rates of patients with esophageal cancer treated by cCRT wre superior to RT, but at the cost of increasing acute adverse reactions.

Clinical trial identification

Disclosure

All authors have declared no conflicts of interest.

Resources from the same session

This site uses cookies. Some of these cookies are essential, while others help us improve your experience by providing insights into how the site is being used.

For more detailed information on the cookies we use, please check our Privacy Policy.

Customise settings