Oops, you're using an old version of your browser so some of the features on this page may not be displaying properly.

MINIMAL Requirements: Google Chrome 24+Mozilla Firefox 20+Internet Explorer 11Opera 15–18Apple Safari 7SeaMonkey 2.15-2.23

Characteristics of endometrial and ovarian cancers in Lynch syndrome and hereditary breast ovarian cancer syndrome

Date

20 Dec 2015

Session

Poster presentation 2

Presenters

Li Min Lim

Citation

Annals of Oncology (2015) 26 (suppl_9): 80-84. 10.1093/annonc/mdv525

Authors

L.M. Lim1, P. Tong2, S.C. Lee3, J. Low2

Author affiliations

  • 1 Obstetrics And Gynaecology, National University Hospital, 119228 - Singapore/SG
  • 2 Obstetrics And Gynaecology, National University Hospital, Singapore/SG
  • 3 Hematology-oncology, National University Hospital, Singapore/SG
More

Resources

Aim/Background

Lynch syndrome and Hereditary Breast Ovarian Cancer (HBOC) syndrome are two hereditary disorders which predispose individuals to gynaecological cancers such as endometrial and ovarian cancer. There may be unique traits in gynaecological cancers arising from these genetic conditions, especially in multi-ethnic populations such as Singapore. We aim to characterize the profiles of endometrial and ovarian cancers in patients diagnosed with Lynch syndrome and the profile of ovarian cancer in patients diagnosed with HBOC in a tertiary institution in Singapore.

Methods

Cases of Lynch and HBOC syndromes were identified from a genetic database between January 2006 and July 2015.

Results

There were 50 cases of Lynch syndrome. 10 patients had gynaecological cancers (7 endometrial cancers, 1 ovarian cancer and 2 synchronous endometrial and ovarian cancers). The mean age of diagnosis was 42 years for endometrial cancer and 43 years for ovarian cancer. All the endometrial cancers belonged to the endometrioid subtype and were Stage 1 diseases. Of the 3 ovarian cancers, 2 were clear cell subtypes and 1 was endometrioid subtype, varying between Stage I to Stage III diseases; there was also one recurrence after adjuvant chemotherapy. 4 of the 10 patients had genetic testing, 2 had mutations in MLH1 gene, 1 had mutation in MSH2 gene and 1 had mutation in MSH6 gene. There were 60 cases of HBOC syndrome and 12 had ovarian cancer. 3 out of these 12 patients had metachronous breast cancer. The mean age of diagnosis of ovarian cancer in HBOC syndrome was 49 years. 8 had BRCA 1 mutations and 4 had BRCA 2 mutations. The majority (8/12) had serous component in the histological subtype. Most (9/12) were advanced staged at diagnosis and half of the cases (6/12) had recurrences as well.

Conclusions

Hereditary endometrial and ovarian cancers tend to be diagnosed at an earlier age. In Lynch syndrome, both cancers appear to be early staged at diagnosis and ovarian cancer was of the non-serous subtypes. In HBOC syndrome, ovarian cancer was predominantly of the serous subtype and more likely to be advanced staged and develop recurrences. Further research is necessary in larger Asian cohorts.

Clinical trial identification

NA

Disclosure

All authors have declared no conflicts of interest.

Resources from the same session

This site uses cookies. Some of these cookies are essential, while others help us improve your experience by providing insights into how the site is being used.

For more detailed information on the cookies we use, please check our Privacy Policy.

Customise settings