Oops, you're using an old version of your browser so some of the features on this page may not be displaying properly.

MINIMAL Requirements: Google Chrome 24+Mozilla Firefox 20+Internet Explorer 11Opera 15–18Apple Safari 7SeaMonkey 2.15-2.23

Poster Display session 2

2263 - Immunohistochemical expression of ER-α and PR in papillary thyroid carcinoma

Date

29 Sep 2019

Session

Poster Display session 2

Presenters

Enas Elkhouly

Citation

Annals of Oncology (2019) 30 (suppl_5): v194-v197. 10.1093/annonc/mdz245

Authors

E.A. Elkhouly1, E. Abdelraziq1, T. Rageh1, M. Serag1, A. Abdou2

Author affiliations

  • 1 Clinical Oncology Department, Faculty of Medicine - Menoufia University, 32511 - Shebin El Kom/EG
  • 2 Pathology, Faculty of Medicine - Menoufia University, 32511 - Shebin El Kom/EG
More

Resources

Abstract 2263

Background

Papillary thyroid carcinoma (PTC) is the most common thyroid cancer with multiple risk factors including exposure to ionizing radiation. Estrogens contribute to papillary carcinoma development by promoting cell proliferation and invasion of mutated epithelial follicular cells. The present study aimed to assess ER-α and PR expression in PTC and to correlate their expression with the clinicopathological parameters in this cancer.

Methods

This study included 62 primary and six metastatic papillary thyroid carcinoma cases.

Results

Nineteen and 38.7% of primary PTC cases showed positive nuclear expression for ER and PR, respectively. Metastatic cases showed 66.7% positive ER expression and all were negative for PR. Estrogen receptor expression showed significant higher positivity in metastatic compared to primary PTC (p = 0.02) and it was significantly associated with primary PTC associated with thyroiditis (p = .002). Progesterone receptor expression was significantly associated with old age in primary PTC (p = .003) and it showed significant coparallel expression with ER (p = .000).

Conclusions

Estrogen and progesterone receptors expressed in papillary thyroid carcinoma opening the door for further studies to verify if those patients could benefit from hormonal therapy. Estrogen receptor seems to have a role in metastatic process of PTC as malignant cells express it in metastatic more than primary site. The presence of lymphocytes in the stroma may promote ER expression in adjacent PTC, necessitating further studies on PTC cases associated with Hashimoto thyroiditis to verify this assumed relationship.

Clinical trial identification

Editorial acknowledgement

Legal entity responsible for the study

The authors.

Funding

Has not received any funding.

Disclosure

All authors have declared no conflicts of interest.

This site uses cookies. Some of these cookies are essential, while others help us improve your experience by providing insights into how the site is being used.

For more detailed information on the cookies we use, please check our Privacy Policy.

Customise settings