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Poster display session: Basic science, Endocrine tumours, Gastrointestinal tumours - colorectal & non-colorectal, Head and neck cancer (excluding thyroid), Melanoma and other skin tumours, Neuroendocrine tumours, Thyroid cancer, Tumour biology & pathology

3074 - Withholding Anti-EGFR: ImpacT on Outcome of RAS wild-type metastatic Colorectal Tumors (WAIT OR ACT): a multicentric AGEO study


21 Oct 2018


Poster display session: Basic science, Endocrine tumours, Gastrointestinal tumours - colorectal & non-colorectal, Head and neck cancer (excluding thyroid), Melanoma and other skin tumours, Neuroendocrine tumours, Thyroid cancer, Tumour biology & pathology


Targeted Therapy

Tumour Site

Colon and Rectal Cancer


Lola-Jade Palmieri


Annals of Oncology (2018) 29 (suppl_8): viii150-viii204. 10.1093/annonc/mdy281


L. Palmieri1, L. Mineur2, D. Tougeron3, B.J. Rousseau4, V. Granger5, J. Gornet6, D. Smith7, A. Lievre8, M.P. Galais9, S. Racine Doat10, S. Pernot11, A.L. Bignon Bretagne12, J. Metges13, N. Baba-Hamed14, M. Hassine15, S. Obled16, C. Vitellius17, O. Bouche18, D. Vernerey19, R. Coriat20

Author affiliations

  • 1 Gastroenterology, Hôpital Cochin, 75014 - Paris/FR
  • 2 Oncology, Institut Ste Catherine, 84082 - Avignon/FR
  • 3 Medical Oncology, CHU Poitiers, Jean Bernard Hôpital, 86021 - Poitiers/FR
  • 4 Medical Oncology, Centre hospitalier universitaire Henri-Mondor, 94010 - Créteil/FR
  • 5 Gastroenterology, Centre Hospitalier Universitaire Grenoble, 38043 - Grenoble/FR
  • 6 Gastroenterology, Hôpital St. Louis, 75010 - Paris/FR
  • 7 Service D'oncologie, CHU Bordeaux Hopital St. André, 33000 - Bordeaux/FR
  • 8 Gastroenterology, CHU de Pontchaillou, 35033 - Rennes/FR
  • 9 Medical Oncology, Centre Francois Baclesse, 14076 - Caen/FR
  • 10 Gastroenterology, Groupe Hospitalier Pitié Salpetriere, 75651 - Paris/FR
  • 11 Department Of Gastroenterology And Digestive Oncology, Hopital European George Pompidou, 75015 - Paris/FR
  • 12 Gastroenterology, CHU de Caen, 14033 - Caen/FR
  • 13 Medical Oncology, C.H.U. Brest - Hôpital Morvan, 29609 - Brest/FR
  • 14 Medical Oncology, Groupe Hospitalier Paris Saint-Joseph, 75014 - PARIS/FR
  • 15 Gastroenterology, CHU de Rouen - Hôpital Charle Nicolle, 76000 - Rouen/FR
  • 16 Medical Oncology, Centre Hospitalier Universitaire Nimes, 30029 - Nimes/FR
  • 17 Gastroenterology, CHU Angers, 49933 - Angers/FR
  • 18 Medical Oncology, CHU de Reims - Hôpital Robert Debré, 51092 - Reims/FR
  • 19 Statistics, CHU Besançon, Hôpital Jean Minjoz, Besançon/FR
  • 20 Gastroenterology, Hôpital Cochin, 75679 - Paris/FR


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Abstract 3074


Two phases III studies (FIRE-3 and CALGB/SWOG80405) suggested higher response rate (RR) for doublet chemotherapy with an anti-EGFR (Epidermal Growth Factor Receptor) compared to an anti-VEGF (Vascular Endothelial Growth Factor), in first line RAS/BRAF wild-type (WT) unresectable metastatic colorectal cancer (mCRC). Unfortunately, in clinical practice the delay to obtain RAS/BRAF status may delay the chemotherapy start. No study has evaluated the impact of a delayed introduction of the anti-EGFR.


This retrospective multicentric AGEO (Association Gastro-Entérologues Oncologues) study included mCRC RAS/BRAF WT patients who received a doublet chemotherapy either with an anti-VEGF introduced immediately (control arm) or with an anti-EGFR introduced at cycle 2 or 3 (delayed group) between 2013 and 2016. The primary endpoint was the Progression Free Survival (PFS). The Overall Survival (OS) and the RR were secondary endpoints. Given different characteristics between the two groups, a propensity score was developed.


A total of 262 patients were included: 129 in the control group and 133 in the delayed group. Compared to the delayed group, patients treated in the control group were more likely descendant mCRC (60% vs 44%) and had more metastatic sites (>1 site: 57% vs 40%). In the delayed anti-EGFR group, the time to obtain RAS status was 20.7 days ±18.9. The anti-EGFR was introduced in 70% of cases at C2 and in 30% at C3. Using the propensity score, there was no more difference between the two groups. The median follow-up was 37.9 months. PFS and RR were significantly longer and higher in the delayed anti-EGFR group compared to the control anti-VEGF group (PFS: 13.8 vs 10.8 months, p = 0.03; RR: 67% vs 46%, p = 0.0007). Meantime, no difference was observed concerning OS (30.4 months vs 30.0 months, p = 0.23).


There is no deleterious effect of delayed anti-EGFR introduction at cycle 2 or 3 compared to the immediate introduction of anti-VEGF in patients with RAS/BRAF WT mCRC. Therefore, in current clinical practice, if the response rate is an important goal, it is possible to wait for RAS status and to initially start chemotherapy without targeted therapy.

Clinical trial identification

Legal entity responsible for the study

Lola-Jade Palmieri.


Has not received any funding.

Editorial Acknowledgement


D. Tougeron: Consulting or advisory role: MSD, BMS, Sanofi, Roche; Speaker’s bureau: Roche, Novartis, Servier; Travel, accomodations, expenses: MSD, BMS, Merck, Amgen. A. Lievre: Consulting or advisory role: Merck, Amgen, Bayer, Ipsen; Speaker’s bureau: Roche, Merck, Ipsen, BMS, Novartis, Servier; Travel, accomodations, expenses: Merck, Novartis, Ipsen, Roche. S. Pernot: Honoraria: Amgen, Sanofi; Travel, accomodations, expenses: Amgen, Merck, Servier, Bayer. O. Bouche: Consulting or advisory role: Roche, Merck, Amgen, Bayer; Speaker’s bureau: Lilly, Pierre Fabre, Novartis, Servier; Travel, accomodations, expenses: Lilly, Roche, Merck. R. Coriat: Amgen, Merck, Roche, Novartis, Ipsen, Keocyt, Bayer, Servier. All other authors have declared no conflicts of interest.

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