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Poster display session: Basic science, Endocrine tumours, Gastrointestinal tumours - colorectal & non-colorectal, Head and neck cancer (excluding thyroid), Melanoma and other skin tumours, Neuroendocrine tumours, Thyroid cancer, Tumour biology & pathology

3270 - Treatment Pattern and Clinical Outcomes of Patients With Locally Advanced and Metastatic Melanoma in a Real-World Setting in China

Date

21 Oct 2018

Session

Poster display session: Basic science, Endocrine tumours, Gastrointestinal tumours - colorectal & non-colorectal, Head and neck cancer (excluding thyroid), Melanoma and other skin tumours, Neuroendocrine tumours, Thyroid cancer, Tumour biology & pathology

Topics

Therapy

Tumour Site

Melanoma

Presenters

Chuanliang Cui

Citation

Annals of Oncology (2018) 29 (suppl_8): viii442-viii466. 10.1093/annonc/mdy289

Authors

C. Cui1, X. Yan2, S. Liu3, A. Deitz4, L. Si5, Z. Chi2, X. Sheng6, B. Lian1, J. Li3, J. Ge3, X. Wang2, L. Mao6, B. Tang6, L. Zhou2, X. Bai6, S. Li2, B. Li3, H. Wu3, J. Guo6

Author affiliations

  • 1 Urology And Melanoma, Beijing Cancer Hospital, 100142 - Beijing/CN
  • 2 Urology And Melanoma, Beijing Cancer Hospital, Beijing/CN
  • 3 Medical Oncology, MSD China, Beijing/CN
  • 4 Medical Oncology, Merck & Co., Inc., Kenilworth/US
  • 5 Department Of Renal Cancer And Melanoma, Peking University Cancer Hospital-Beijing Cancer Hospital, 100142 - Beijing/CN
  • 6 Urology And Melanoma, Beijing Cancer Hospital, 100000 - Beijing/CN
More

Resources

Abstract 3270

Background

In China, treatment options for late-stage melanoma, particularly for second-line (2L) therapy, are limited. This retrospective, observational study used electronic medical records (EMRs) of patients (pts) with melanoma treated at Beijing Cancer Hospital (BCH) to describe the treatment pattern and real-world clinical outcomes in locally advanced, metastatic melanoma in China.

Methods

All adult pts with unresectable stage III or IV melanoma who initiated treatment between Jan 1, 2014, and Dec 31, 2015, were eligible. Pts were treated and followed up with regular imaging (every 3 mo). Trained researchers performed additional medical chart reviews to supplement data captured in the EMR database. Complete or partial responses, per RECIST v1.1 were adjudicated case by case. Survival analysis involved the Kaplan-Meier method, pts were censored at last known date alive before Dec 31, 2017.

Results

Of 248 pts included in the study, 40.7% and 30.6% had acral and mucosal histology, respectively; almost all (∼95%) had stage IV melanoma; 221 received first-line (1L) therapy and 116 received 2L therapy (89 received both at BCH within the treatment period). The most common 1L regimens were dacarbazine + cisplatin + recombinant human endostatin (RHE) (36.7%) and paclitaxel + carboplatin + bevacizumab (22.2%). The most common 2L regimens were paclitaxel albumin + carboplatin + bevacizumab (22.4%), paclitaxel + carboplatin + RHE (15.5%) and paclitaxel albumin + cisplatin + RHE (12.1%). Clinical outcomes in pts with advanced melanoma are summarized in the table and are generally unfavorable: ORR <10%; median PFS <4 months; median OS < 1 year. Median DOR was 9.1 mo for 1L and 7.5 mo for 2L therapy.Table: 1283P

1L Therapy (N = 221)2L Therapy (N = 116)
Response
CR, n20
PR, n124
ORR, % (95% CI)6.3% (3.5-10.4)3.4% (0.9-8.6)
Median DOR (range), months9.1 (1.7-28.4+)7.5 (4.6-24.2+)
Median PFS (95% CI), months3.5 (2.9-4.2)2.3 (2.0-3.0)
12-month PFS rate10.6%5.2%
Deaths, n (%)171 (77.4)101 (87.1)
Median OS (95% CI), months10.5 (9.2-12.1)7.5 (6.5-8.7)
12-month OS rate43.5%30.5%

CI, confidence interval; CR, complete response; DOR, duration of response; 1L, first-line therapy; 2L, second-line therapy; ORR, objective response rate; OS, overall survival; PR, partial response; PFS, progression-free survival.

Conclusions

The poor outcomes observed in this study suggest a high degree of unmet medical need for advanced melanoma in China in both the 1L and 2L settings.

Clinical trial identification

Legal entity responsible for the study

Merck & Co., Inc.

Funding

Merck & Co., Inc.

Editorial Acknowledgement

Medical writing and/or editorial assistance was provided by Doyel Mitra, PhD, of the ApotheCom pembrolizumab team, Yardley, PA, USA. This assistance was funded by Merck & Co., Inc., Kenilworth, NJ, USA.

Disclosure

C. Cui, X. Yan, L. Si, Z. Chi, X. Sheng, X. Wang, L. Mao, B. Tang, L. Zhou, X. Bai, S. Li: Research funding: Merck & Co., Inc. S. Liu, J. Li, J. Ge, H. Wu: Employee, Stockholder: MSD China. A. Deitz: Employee, Stockholder: Merck & Co., Inc. B. Lian: Research funding: Merck. B. Li: Employee: MSD China. J. Guo: Research funding, Advisory board: Merck & Co., Inc.

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