Abstract 1673
Background
Studies have shown that Enhancer-of-zeste homologue 2 (EZH2) plays an important role in carcinogenesis in the breast cancer, and invasion and progression of the disease. We aimed to assess the prognostic value of different molecular subtypes of breast cancer in relation to EZH2 expression.
Methods
We performed a cross-sectional analytical research study on 100 breast cancer women. Survival analysis was then performed using the Kaplan–Meier method, with log-rank tests to assess statistical significance between groups. To assess the effects of variables on OS and DFS, a Cox proportional-hazard model was then used to give adjusted hazard ratios (HRs) with 95% confidence intervals (CIs).
Results
Samples were collected for 100 women with breast cancers, with follow-up data collected over a 5-year period. The mean age was 51.5 ± 9.54 years (range, 34–75 years), By molecular subgroup, 43% had luminal A tumors, 41% had luminal B tumors, 9% had HER2 tumors, and 7% had TNBC tumors. Overall, 74% had high EZH2 expression, which was most common for the luminal A subtype (43.2%) and least common for the TNBC subtype (8.1%). There was no significant correlation between subgroups by EZH2 expression (P = 0.33).
Conclusions
In conclusion, although our results provide some interesting insights, there remains controversy about the prognostic value of different molecular subtypes of breast cancer in relation to EZH2 expression. Given that there are very few studies on this topic, we advocate further research with larger sample sizes and the inclusion of molecular techniques.
Clinical trial identification
This study was conducted as part of a fellowship thesis for Dr Boostani (thesis no 94/5-9/30). Dr Robert Sykes (www.doctored.org.uk) provided technical editing services for the final drafts of this manuscript.
Legal entity responsible for the study
The study protocol was approved by the ethics committee of Tabriz University (permit no. 5/d/988072).
Funding
Hematology and Oncology Research Center, Tabriz University of Medical Science, Tabriz, Iran.
Editorial Acknowledgement
This study was conducted as part of a fellowship thesis for Dr Boostani (thesis no 94/5-9/30). Dr Robert Sykes (www.doctored.org.uk) provided technical editing services for the final drafts of this manuscript.
Disclosure
All authors have declared no conflicts of interest.
Resources from the same session
1159 - Molecular characterization and search for founding effects in Canarian families with Hereditary Breast and Ovarian Cancer Syndrome
Presenter: Elisenda Llabres Valenti
Session: Poster display session: Basic science, Endocrine tumours, Gastrointestinal tumours - colorectal & non-colorectal, Head and neck cancer (excluding thyroid), Melanoma and other skin tumours, Neuroendocrine tumours, Thyroid cancer, Tumour biology & pathology
Resources:
Abstract
3725 - Effect of the polymorphism rs2066844 of the NOD2 gene on colon cancer incidence in a high cardiovascular risk population. Modulation by gender
Presenter: Judith Begona Ramirez Sabio
Session: Poster display session: Basic science, Endocrine tumours, Gastrointestinal tumours - colorectal & non-colorectal, Head and neck cancer (excluding thyroid), Melanoma and other skin tumours, Neuroendocrine tumours, Thyroid cancer, Tumour biology & pathology
Resources:
Abstract
3708 - Effect of the polymorphisms rs1476413, rs1801131, rs4846052 and rs6541003 of the MTHFR gene on prostate cancer in a high cardiovascular risk population
Presenter: Judith Begona Ramirez Sabio
Session: Poster display session: Basic science, Endocrine tumours, Gastrointestinal tumours - colorectal & non-colorectal, Head and neck cancer (excluding thyroid), Melanoma and other skin tumours, Neuroendocrine tumours, Thyroid cancer, Tumour biology & pathology
Resources:
Abstract
5057 - Association of a genetic variant in cyclin-dependent kinase Inhibitor 2A gene with the increased risk of breast cancer
Presenter: Soodabeh Shahid Sales
Session: Poster display session: Basic science, Endocrine tumours, Gastrointestinal tumours - colorectal & non-colorectal, Head and neck cancer (excluding thyroid), Melanoma and other skin tumours, Neuroendocrine tumours, Thyroid cancer, Tumour biology & pathology
Resources:
Abstract
5970 - Investigating the role of HAT protein TIP60 in regulating functional dynamics of nuclear receptor PXR
Presenter: KARISHMA BAKSHI
Session: Poster display session: Basic science, Endocrine tumours, Gastrointestinal tumours - colorectal & non-colorectal, Head and neck cancer (excluding thyroid), Melanoma and other skin tumours, Neuroendocrine tumours, Thyroid cancer, Tumour biology & pathology
Resources:
Abstract
1360 - The role of downregulated SIRT3 expression in patients with hepatocellular carcinoma
Presenter: Hanhee Jo
Session: Poster display session: Basic science, Endocrine tumours, Gastrointestinal tumours - colorectal & non-colorectal, Head and neck cancer (excluding thyroid), Melanoma and other skin tumours, Neuroendocrine tumours, Thyroid cancer, Tumour biology & pathology
Resources:
Abstract
1634 - Prediction and Intervention of Colorectal Cancer Risk with Artificial Intelligent System
Presenter: Yang Ge
Session: Poster display session: Basic science, Endocrine tumours, Gastrointestinal tumours - colorectal & non-colorectal, Head and neck cancer (excluding thyroid), Melanoma and other skin tumours, Neuroendocrine tumours, Thyroid cancer, Tumour biology & pathology
Resources:
Abstract
4921 - Measuring the Efficiency of Cancer Care in Europe
Presenter: Rikard Althin
Session: Poster display session: Basic science, Endocrine tumours, Gastrointestinal tumours - colorectal & non-colorectal, Head and neck cancer (excluding thyroid), Melanoma and other skin tumours, Neuroendocrine tumours, Thyroid cancer, Tumour biology & pathology
Resources:
Abstract
1235 - Circulating cell-free DNA isolated from plasma of mesenteric veins predicts prognosis in stage II colorectal cancer patients
Presenter: Chih-Yung Yang
Session: Poster display session: Basic science, Endocrine tumours, Gastrointestinal tumours - colorectal & non-colorectal, Head and neck cancer (excluding thyroid), Melanoma and other skin tumours, Neuroendocrine tumours, Thyroid cancer, Tumour biology & pathology
Resources:
Abstract
5169 - _lonality of uterine carcinosarcoma as a factor of clinical prognosis.
Presenter: Natalia Levitskaya
Session: Poster display session: Basic science, Endocrine tumours, Gastrointestinal tumours - colorectal & non-colorectal, Head and neck cancer (excluding thyroid), Melanoma and other skin tumours, Neuroendocrine tumours, Thyroid cancer, Tumour biology & pathology
Resources:
Abstract