Abstract 2848
Background
Although recent years have seen improvement in systemic therapies and radiotherapy, the surgical approach is still a keystone in oncologic treatment. In this study we investigated the association between surgical margin status and surgical approach with disease progression and death of breast cancer patients treated in the Oncology Sector of a Public Hospital of Minas Gerais.
Methods
Observational and retrospective study: A total of 1979 medical records of women with breast cancer treated in the period of 1981 to 2013 were analyzed. The surgical approach and surgical margin were obtained from anatomopathological reports. Of the total, 987 were excluded for lack of pathologic data, being diagnosed at stage IV or pathogical 0 stage.
Results
Of the subtotal, 992 medical records reported the surgery approach (radical or breast-conserving), and 905 reported surgical margins, of which 110 had positive margin and 795 negative margin. The median age was of 55 y.o. (27-91). It was observed that 49.69% (n = 493) of surgeries were breast-conserving. No association between surgical approach and local relapse (p = 0.2672) was observed. However, increased odds of surgical margin impairment (OR = 1.531; p = 0.0395) and decreased odds of distant relapse (OR = 0.4068; p < 0.0001) and death (OR = 0.1455; p < 0.0001) was observed for breast-conserving surgeries compared with radical surgeries. No association between surgical margin and local relapse was observed (p = 0.1063). However, patients with positive surgical margin had greater odds of distant relapse (OR = 1.940; p = 0.0052) and death (OR = 2.002; p = 0.0494). When analyzed by pathological stage (I-III), it was observed that positive surgical margin increased the odds of distant relapse in stage II (OR = 2.280; p = 0.00499) and III (OR = 2.820; p = 0.0132) patients.
Conclusions
Although an association between radical surgery and death was observed, factors such as tumor complexity and locally advanced tumor could be involved. However, it is noteworthy that positive surgical margin increased the odds of distant relapse, mainly in stage III patients, and death. These data corroborate the fact that the surgical approach is still a keystone in breast cancer treatment and it has a strong impact in patients with locally advanced tumors.
Clinical trial identification
Legal entity responsible for the study
Grupo Luta Pela Vida.
Funding
Grupo Luta Pela Vida.
Editorial Acknowledgement
Disclosure
All authors have declared no conflicts of interest.
Resources from the same session
1159 - Molecular characterization and search for founding effects in Canarian families with Hereditary Breast and Ovarian Cancer Syndrome
Presenter: Elisenda Llabres Valenti
Session: Poster display session: Basic science, Endocrine tumours, Gastrointestinal tumours - colorectal & non-colorectal, Head and neck cancer (excluding thyroid), Melanoma and other skin tumours, Neuroendocrine tumours, Thyroid cancer, Tumour biology & pathology
Resources:
Abstract
3725 - Effect of the polymorphism rs2066844 of the NOD2 gene on colon cancer incidence in a high cardiovascular risk population. Modulation by gender
Presenter: Judith Begona Ramirez Sabio
Session: Poster display session: Basic science, Endocrine tumours, Gastrointestinal tumours - colorectal & non-colorectal, Head and neck cancer (excluding thyroid), Melanoma and other skin tumours, Neuroendocrine tumours, Thyroid cancer, Tumour biology & pathology
Resources:
Abstract
3708 - Effect of the polymorphisms rs1476413, rs1801131, rs4846052 and rs6541003 of the MTHFR gene on prostate cancer in a high cardiovascular risk population
Presenter: Judith Begona Ramirez Sabio
Session: Poster display session: Basic science, Endocrine tumours, Gastrointestinal tumours - colorectal & non-colorectal, Head and neck cancer (excluding thyroid), Melanoma and other skin tumours, Neuroendocrine tumours, Thyroid cancer, Tumour biology & pathology
Resources:
Abstract
5057 - Association of a genetic variant in cyclin-dependent kinase Inhibitor 2A gene with the increased risk of breast cancer
Presenter: Soodabeh Shahid Sales
Session: Poster display session: Basic science, Endocrine tumours, Gastrointestinal tumours - colorectal & non-colorectal, Head and neck cancer (excluding thyroid), Melanoma and other skin tumours, Neuroendocrine tumours, Thyroid cancer, Tumour biology & pathology
Resources:
Abstract
5970 - Investigating the role of HAT protein TIP60 in regulating functional dynamics of nuclear receptor PXR
Presenter: KARISHMA BAKSHI
Session: Poster display session: Basic science, Endocrine tumours, Gastrointestinal tumours - colorectal & non-colorectal, Head and neck cancer (excluding thyroid), Melanoma and other skin tumours, Neuroendocrine tumours, Thyroid cancer, Tumour biology & pathology
Resources:
Abstract
1360 - The role of downregulated SIRT3 expression in patients with hepatocellular carcinoma
Presenter: Hanhee Jo
Session: Poster display session: Basic science, Endocrine tumours, Gastrointestinal tumours - colorectal & non-colorectal, Head and neck cancer (excluding thyroid), Melanoma and other skin tumours, Neuroendocrine tumours, Thyroid cancer, Tumour biology & pathology
Resources:
Abstract
1634 - Prediction and Intervention of Colorectal Cancer Risk with Artificial Intelligent System
Presenter: Yang Ge
Session: Poster display session: Basic science, Endocrine tumours, Gastrointestinal tumours - colorectal & non-colorectal, Head and neck cancer (excluding thyroid), Melanoma and other skin tumours, Neuroendocrine tumours, Thyroid cancer, Tumour biology & pathology
Resources:
Abstract
4921 - Measuring the Efficiency of Cancer Care in Europe
Presenter: Rikard Althin
Session: Poster display session: Basic science, Endocrine tumours, Gastrointestinal tumours - colorectal & non-colorectal, Head and neck cancer (excluding thyroid), Melanoma and other skin tumours, Neuroendocrine tumours, Thyroid cancer, Tumour biology & pathology
Resources:
Abstract
1235 - Circulating cell-free DNA isolated from plasma of mesenteric veins predicts prognosis in stage II colorectal cancer patients
Presenter: Chih-Yung Yang
Session: Poster display session: Basic science, Endocrine tumours, Gastrointestinal tumours - colorectal & non-colorectal, Head and neck cancer (excluding thyroid), Melanoma and other skin tumours, Neuroendocrine tumours, Thyroid cancer, Tumour biology & pathology
Resources:
Abstract
5169 - _lonality of uterine carcinosarcoma as a factor of clinical prognosis.
Presenter: Natalia Levitskaya
Session: Poster display session: Basic science, Endocrine tumours, Gastrointestinal tumours - colorectal & non-colorectal, Head and neck cancer (excluding thyroid), Melanoma and other skin tumours, Neuroendocrine tumours, Thyroid cancer, Tumour biology & pathology
Resources:
Abstract